Dr Giulia Getti

Giulia Getti PhD

Dr Giulia Getti

Giulia T M Getti
PhD

Senior Lecturer, Microbiology

Department of Life & Sports Sciences

Faculty of Engineering & Science

Dr Giulia Getti graduated from the University of Perugia, Italy, in July 2000 with a degree in biological science, specialising in microbiology and molecular biology. She worked as a research assistant at Perugia University for a year and in 2003 moved to the University of Greenwich to start a PhD on 'Interaction between Leishmania parasites and mammalian macrophages'.

In 2006, Dr Getti started working at the University of East London as a research fellow developing standard protocols in proteomics and MALDI-TOF based analytical techniques for the analysis of microbial protein expression. She joined the University of Greenwich in 2008 as a senior lecturer in microbiology.

Course coordinator

  • Pharmaceutical Microbiology and an introduction to Biotechnology
  • Medical Microbiology.

Course participation

  • Cell and Microbial Biology
  • Human Molecular Biology
  • Immunology
  • Introduction to Medical Science
  • Pharmaceutics.

Dr Getti's research focuses on the study of the interaction between Leishmania parasites and mammalian macrophages.

Leishmania is a digenetic protozoan parasite whose life cycle alternates between two stages, an extracellular promastigote stage (carried by host sandfly) and intracellular amastigotes (inside human host cells). Once the parasite has established itself inside host macrophages, it spreads causing a variety of symptoms ranging from skin lesion to visceral involvement and death. No vaccine or suitable cure is available to date. Dr Getti's research concentrates on the infection stage relevant to the disease: the intracellular amastigote stage.

Study of the intracellular stage is challenging for a number of reasons, one of which is that detection and monitoring of infection takes place through time consuming techniques such as GIEMSA stain and microscopic counting. Dr Getti's research group has worked on this problem and generated GFP-expressing parasites (L. aethiopica, L. major, L. tropica and L. mexicana) that allow the automatized detection of infection via flow cytometry. This model has also been successfully validated for in-vitro screening of novel compounds on intracellular parasites. They are currently looking at the possibility of using our GFP-expressing parasites for in-vivo studies.

The mechanism through which the parasites survive and spread inside the human host is far from understood and the group are looking at it from a number of points.

A comparative proteomic study of the infection process of 4 parasite species is under way and it will give an overview of those proteins that are contributing to the disease development and are therefore possible targets for therapies.

A number of infectious organisms are well known to interfere with host cell apoptosis, ability to regulate this process is likely to greatly contribute to the success of the infection. Dr Getti's research group are looking at elucidating the effect of Leishmania at various stages of infection on host cell apoptosis.

The ability of the parasites to express specific membrane proteins at various stages of it life cycle as well as during infection is under study. Families of proteins that have been found in a number of organisms and are responsible for cellular processes essential for survival have been identified and their expression studied.

Leishmania parasites can successfully establish themselves in the human host thanks to their ability to use the very cell that should be killing infectious organisms. The results of this research will support the much needed understanding of the basic biology behind this infection. Moreover this research has the potential to greatly impact on the search and development of novel treatment against leishmaniasis.

, , , and () . Parasitology. Cambridge University Press. pp. 1-10. ISSN 0031-1820 ISSN 0031-1820

, , and () . Journal of Colloid and Interface Science. Elsevier. pp. 221-233. ISSN 0021-9797 ISSN 0021-9797

, , , , , , , , , and () . Biochimica et Biophysica Acta (BBA) - General Subjects. Elsevier. pp. 1541-1550. ISSN 0304-4165 ISSN 0304-4165

, , and () . Lindbergia. Nordic Bryological Society and the Dutch Bryological and Lichenological Society. pp. 39-43. ISSN 2001-5909 ISSN 2001-5909

, , , , , and () . International Journal of Pharmaceutics. Elsevier. pp. 161-171. ISSN 0378-5173 ISSN 0378-5173

, and () . International Journal of Biological Macromolecules. Elsevier B.V.. pp. 11-16. ISSN 0141-8130 ISSN 0141-8130

, and () . Parasitology. Cambridge University Press. pp. 501-510. ISSN 0031-1820 ISSN 0031-1820

, and () . World Academy of Science Engineering and Technology. In: World Academy of Science Engineering and Technology. World Academy of Science Engineering and Technology. pp. 478-482. ISSN 2010-376X ISSN 2010-376X

, , , , , , and () . Tetrahedron Letters. Elsevier. pp. 3607-3611. ISSN 0040-4039 ISSN 0040-4039

, , , , , and () . Journal of Parasitology. Allen Press Publishing / American Society of Parasitologists. pp. 456-460. ISSN 0022-3395 ISSN 0022-3395

, and () . Indian Journal of Pharmacology. Medknow Publications. pp. 32-35. ISSN 0253-7613 ISSN 0253-7613

Browse our research at GALA

, , and () . In: Worldleish5 Fifth world congress on leishmaniasis. www.worldleish5.org.

, , , , and () . In: ICOPA XII 2010. Medimond, XII International Congress of Parasitology ICOPA. ISBN 978-88-7587-598-5

Browse our research at GALA