Paul Dyer BSc, MSc, FIBMS
BSc, MSc, FIBMS
Principal Lecturer, Biomedical Science; Head of Biomedical Sciences
Department of Life & Sports Sciences
Faculty of Engineering & Science
Dr Paul Dyer, having received his degree BSc (Hons) in Biomedical Science, joined Bart's and The London NHS Trust as a HCPC registered Biomedical Scientist in Haematology and Blood Transfusion, finally specialising in Stem Cell and Bone Marrow Transplantation.
In 2006 he joined the University of Greenwich as a Senior Lecturer in Biomedical Science, becoming Principal Lecturer and Head of Biomedical Sciences in April 2012. Dr Dyer is currently the programme director for the BSc (Hons) Biomedical Science and BSc (Hons) Applied Biomedical Science degree programmes.
Since completing his PhD in gene and antisense delivery, Dr Dyer has been pursuing his own research interests in novel macromolecular delivery technologies, with a particular interest in cell-based immunotherapies.
- BSc (Hons) Biomedical Science
- BSc (Hons) Applied Biomedical Science
- Introduction to Medical Science
- Professional Practice in Biomedical Science
- Haematology and Blood Transfusion
- Advanced and Clinical Immunology
- Medical Biochemistry
- Cell and Microbial Biology
Current MPhil / PhD Supervisions
- Mr Alex Gollings (Started 2014)
- Mr Dongchu Wang (Started 2013)
- Ms Susan Shorter (Started 2012)
- Mehak Rafiq (Faculty of Engineering and Science)
Health and Care Professions Council: Registered BMS (BS41478)
Institute of Biomedical Science: Fellow
Biochemical Society: Member
American Society of Cell Biology: Member
Protein Society: Member
Immunology and Infectious Disease (Horizon Publishing)
Novel Protein Based Drug Delivery Systems
The delivery of macromolecules to the cytosol of a cell has been, and continues to be, a significant challenge for molecules such as protein, DNA and RNA. A number of protein toxins have been previously shown to mediate entry to the cytosol whereby they can exert their toxic effect upon the cell. The development of attenuated toxins to mediate cytosolic delivery of therapeutic macromolecules has the potential to treat a variety of diseases at the molecular level.
Investigation of Toxin Pore Biology
Natural protein toxins mediate toxicity through the translocation of a catalytically active component into the cytosol. In many cases this requires the development of intricate architecture in the form of a protein pore allowing for cytosolic access. The investigation of this system using circular dichroism spectroscopy, high-sensitivity differential scanning calorimetry, and neutron reflectometry will allow for further characterisation of its limitations in both pathology and drug delivery.
Oral Vaccine Delivery System
The method of delivery of vaccines targeting a variety of common diseases is a worldwide problem. Cold chain storage presents a significant challenges in developing nations. The principle routes of administration for current vaccines include subcutaneous and intramuscular injections. The development of safe and effective oral based vaccine using attenuated toxins to mediate translocation across gut epithelia is of interest. Additionally, coating protein loaded silica nanoparticles with an enteric coat provides protection against the low pH and proteases commonly found in the stomach, whilst maintaining the integrity of the protein delivery system. This has the potential to mitigate against the high cost of cold chain storage and vaccine administration providing an opportunity to prevent diseases common to developing nations
Technology Enhanced Learning
The use of technology to enhance student learning is a fast moving area. Students in Science have had access to iPads to support laboratory practice and acquisition of practical skills. The iPad project is currently being extended to incorporate technology enhanced learning, using mobile apps to support student engagement and achievement. In addition a project to investigate the role of technology in the development of digital identity and literacy for employability is currently in development.
Takeda UK - Clinical Biochemistry, Haematology and Pathology training for the Pharmaceutical Industry.
Shorter, Susan, Gollings, Alexander, Gorringe-Pattrick, Monique, Coakley, Emma, Dyer, Paul D.R. and Richardson, Simon (2016) The potential of toxin-based drug delivery systems for enhanced nucleic acid therapeutic delivery. Expert Opinion on Drug Delivery. Taylor & Francis. ISSN 1742-5247 ISSN 1742-5247
Dyer, Paul D.R., Shepherd, Thomas R., Gollings, Alexander S., Shorter, Susan A., Gorringe-Pattrick, Monique A. M., Tang, Chun-Kit, Cattoz, Beatrice N., Baillie, Les, Griffiths, Peter C. and Richardson, Simon C.W. (2015) Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity. Journal of Controlled Release. Elsevier B.V.. pp. 316-328. ISSN 0168-3659 ISSN 0168-3659
Pettit, Marie, Dyer, Paul D.R., Mitchell, John C., Griffiths, Peter C., Alexander, Bruce, Cattoz, Beatrice, Heenan, Richard K., King, Stephen M., Schweins, Ralf, Pullen, Frank, Wicks, Stephen R. and Richardson, Simon C.W. (2014) Construction and physiochemical characterisation of a multi-composite, potential oral vaccine delivery system (VDS). International Journal of Pharmaceutics. Elsevier B.V.. pp. 264-271. ISSN 0378-5173 ISSN 0378-5173
Griffiths, Peter C., Mauro, Nicolo, Murphy, Damien M., Carter, Emma, Richardson, Simon C.W., Dyer, Paul and Ferruti, Paolo (2013) Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems. Macromolecular Bioscience. WILEY-VCH Verlag GmbH & Co. KGaA. pp. 641-649. ISSN 1616-5187 ISSN 1616-5187
Dyer, Paul D.R. and Richardson, Simon C.W. (2011) Delivery of biologics to select organelles – the role of biologically active polymers. Expert Opinion on Drug Delivery. Informa Plc. pp. 403-407. ISSN 1742-5247 ISSN 1742-5247
Dyer, Paul D.R., Kotha, Arun K., Pettit, Marie W. and Richardson, Simon C.W. (2013) Imaging select mammalian organelles using fluorescent microscopy: application to drug delivery. In: Methods in Molecular Biology: Cellular and subcellular nanotechnology. Humana Press, New York, USA. pp. 195-210. ISBN 9781627033350