Skip navigation

Dr Simon Richardson

Simon Richardson MSB, CBiol

Dr Simon Richardson

Simon C W Richardson
MSB, CBiol

Senior Lecturer, Biopharmaceutical Sciences

Department of Life & Sports Sciences

Faculty of Engineering & Science

Dr Simon Richardson, having received a BSc Hons in Ecology and Biotechnology, became interested in the modulating the regulation of genes as part of a Master's degree placement at Eli Lilly. After studying gene delivery and completing his PhD at the University of London, School of Pharmacy, he moved to Iowa, USA, to study cell biology (endocytosis and the regulation of membrane trafficking) as well as human gross anatomy which he taught as a Visiting Assistant Professor (Department of Anatomy and Cell Biology, University of Iowa).

Since 2007, Dr Richardson has been actively pursuing his own research interests combining molecular cell biology and drug delivery with the intention of developing new and more efficient anti-viral and anti-cancer medicines based upon nano-scale molecular medicines.

  • Chair of the University Biological and Genetic Modification Safety Committee
  • University Biological Safety Officer
  • Chair of the Faculty of E-S Research Ethics Committee
  • Faculty Research Ethics Committee representative to the University Research Ethics Committee
  • School of Science Research and Enterprise Committee.

Course participation

  • Physiology and Pharmacology
  • Physiological Systems and Regulation
  • Analytical Biochemistry and Advanced Protein Biochemistry
  • Cell and Microbial Biology
  • Medicinal Chemistry and Therapeutics
  • Drug Design and Delivery
  • Medical Microbiology.

Current MPhil / PhD supervisions

  • Mr Dongchu Wang (Started 2013)
  • Ms Susan Shorter (started 2012)
  • Mr Paul Dyer (0.5 FTE) (Transferred 12/2012)
  • Mr Fredrick Momoh (MPhil)
  • Dr Tatiana Christides (0.5 FTE) (Transfer pending)
  • Claudia Cella, Advanced Biomaterials Platform, University of Milan, Italy (Started 2013).

Successful PhD supervisions

  • Ms Marie Pettit
  • Dr Fabio Fenili (University of Milan, Italy)
  • Dr Arun Kumar Kotha (University of Greenwich, UK).

PhD examinations

  • Julie Dubois (Medway School of Pharmacy)
  • Samiyah Hamid (School of Science)
  • Edward Sayers (Cardiff University)

Affiliations

  • Controlled Release Society (USA): Member
  • American Society of Cell Biology: Member
  • Society of Biology (UK): Member (MSB), Chartered Biologist (CBiol)
  • Cardiff Institute of Tissue Engineering and Repair: Member
  • Academy of Pharmaceutical Sciences: Member
  • Oligonucleotide Therapeutic Society: Member

Editorial boards

  • The Journal of Pharmaceutics
  • Molecular and Clinical Pharmacology

Dr Richardson reviews for:

  • The Wellcom Trust
  • BBSRC
  • BigC
  • Journal of Controlled Release

In order to maintain homeostatic balance, mammalian cells compartmentalise, store and process material within organelles. In order to interact with and manipulate their environment, cells move material between membrane bound organelles in a highly regulated way. A well-studied example of one such process is that of endocytosis. Endocytosis is mediated by a succession of cargo sorting, membrane envagination, membrane fission, transport and fusion events that can result in the selective trafficking of both endogenous and exogenous material.

The regulated movement of membrane, and the proteins responsible for the regulation of cargo sorting, vesicle fission (budding), vesicle movement and subsequent fusion is collectively called membrane trafficking and is not limited to endocytosis but also incorporates processes such as organelle biogenesis and the secretion of biogenic signalling molecules.

Once the proteins responsible for regulating and mediating transport from one organelle to another have done their job, they are subject to retrieval (or retention) and this recycling process enables them to participate in subsequent rounds of sorting and movement. Several organisms (both bacterial and plant in origin) have evolved to take advantage of different steps associated with the retention and recycling of membrane components. Ribosome Inactivating Proteins (RIPs) are examples of molecules that can successfully escape the default endocytic pathway entering the cytosol to mediate intoxication resulting in cell death.

This phenomena is interesting as it demonstrates that it is possible to utilise the mammalian endomembrane system to effectively deliver a macromolecule to the cytosol of a cell, a goal that is also sought after by people attempting gene therapy. If these toxins can be made safe, (or used to identify the endogenous recycling domains they mimic) so facilitating the cytosolic delivery of macromolecular drugs, we may force a paradigm shift in both drug discovery and drug delivery.

Further a biocompatible water soluble polymer component can be used to facilitate the cell, tissue or organ specific delivery of this intracellular delivery system. A cartoon depicting this delivery system is shown.

, and () . Journal of Drug Targeting. Taylor & Francis. pp. 757-758. ISSN 1061-186X ISSN 1061-186X

, , , , , and () . Journal of Drug Targeting. Taylor & Francis. pp. 809-817. ISSN 1061-186X ISSN 1061-186X

, , , and () . Parasitology. Cambridge University Press. pp. 1912-1921. ISSN 0031-1820 ISSN 0031-1820

, , , , and () . Expert Opinion on Drug Delivery. Taylor & Francis. pp. 685-696. ISSN 1742-5247 ISSN 1742-5247

, , , , and () . Journal of Nanomedicine and Nanotechnology. OMICS International. pp. 363-372. ISSN 2157-7439 ISSN 2157-7439

, , , , , , , , , and () . Biochimica et Biophysica Acta (BBA) - General Subjects. Elsevier. pp. 1541-1550. ISSN 0304-4165 ISSN 0304-4165

, , , , , , , , and () . Journal of Controlled Release. Elsevier B.V.. pp. 316-328. ISSN 0168-3659 ISSN 0168-3659

, , , and () . International Journal of Biological Macromolecules. Elsevier. pp. 137-150. ISSN 0141-8130 ISSN 0141-8130

, , , , , , , , , , and () . International Journal of Pharmaceutics. Elsevier B.V.. pp. 264-271. ISSN 0378-5173 ISSN 0378-5173

, , , , , and () . Macromolecular Bioscience. WILEY-VCH Verlag GmbH & Co. KGaA. pp. 641-649. ISSN 1616-5187 ISSN 1616-5187

and () . Molecular Pharmaceutics. ACS Publications. pp. 2380-2402. ISSN 1543-8384 ISSN 1543-8384

, , and () . Therapeutic Delivery. Future Science Ltd.. pp. 907-917. ISSN 2041-5990 ISSN 2041-5990

and () . Expert Opinion on Drug Delivery. Informa Plc. pp. 403-407. ISSN 1742-5247 ISSN 1742-5247

, , , , , , and () . The Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. pp. 17079-17090. ISSN 0021-9258 ISSN 0021-9258

, and () . Molecular Pharmaceutics. American Chemical Society. pp. 510-521. ISSN 1543-8384 ISSN 1543-8384

Browse our research at GALA

, , and () . In: Methods in Molecular Biology: Cellular and subcellular nanotechnology. Humana Press, New York, USA. pp. 195-210. ISBN 9781627033350

, , , , , and () . In: Nanomedicine and Drug Delivery. Apple Academic Press Inc., Toronto, Canada & New Jersey, USA.. pp. 51-64. ISBN 978-1-926895-17-8 (hardback), 978-1-46-656007-9 (e-book)

() . In: Organelle-Specific Pharmaceutical Nanotechnology. John Wiley & Sons, Inc.. pp. 177-192. ISBN 9780470631652

Browse our research at GALA