Dionysios Douroumis

Professor Dionysios Douroumis PGCert, PhD

Professor in Pharmaceutical Technology and Process Engineering; Director of Centre for Research Innovation (CRI)

Key details

Professor Dionysios Douroumis

Professor in Pharmaceutical Technology and Process Engineering; Director of Centre for Research Innovation (CRI)

Professor Dennis Douroumis obtained his BSc in Chemistry and PhD from the Department of Pharmacy at Patras University in Greece. He worked as a postdoctoral fellow (2004) at the Friedrich–Schiller University of Jena, Department of Pharmacy for the development of parenteral formulations of antiepileptic drugs (Novartis Pharma, Basel). He also worked as a team leader (2005) in the development of nano-liposomal formulations and treatment of rheumatoid arthritis by applying photodynamic therapy (Biolitec Pharma GmbH.) Following this, he worked for Phoqus Pharmaceutical plc as a senior scientist at the product development department.

His research area focuses on the development of secondary continuous manufacturing by using hot melt extrusion (HME) of extrusion granulation coupled with PAT tools. His group is also involved in development of targeted anticancer drug delivery systems such as SLNs or NLCs produced by high-pressure homogenization. Finally he is actively involved in ink jetting and 3D printing technologies for the development of medical devices (e.g. microneedles, stents) and personalized medicines.

He has published more than 80 research articles, 7 book chapters and edited two books on HME and the delivery of water insoluble APIs. He has patented two proprietary technologies on the coating of transdermal microneedles and printing of drug eluting stents. Professor Douroumis has delivered keynote presentations at national and international conferences while his group presented several poster presentations.

Pharmaceutical science Science

Chemistry

Responsibilities within the university

Course participation

  • Drug Design and Delivery
  • Pharmaceutical Product Development, Manufacture and Control

Research group

  • Dr Nikolaos Scoutaris (Research Associate)
  • Dr Mary Malamatary (Research Associate)
  • Steven Ross
  • Tumpa Dey
  • Md Sadeque Mithu
  • Jaya Chakraborty
  • Parastou Emami
  • Chris Pissinato
  • Syed Haque

Previous Members

  • Dr Mohammed Maniruzzaman
  • Dr Katarzina Migalska
  • Dr Olga Labovitiadi
  • Dr Ichioma Onyesom
  • Dr Md Jasim Uddin
  • Dr Kapil Kumar Vithani
  • Dr Hiren Moradiya
  • Dr Tariq Islam
  • Dr Mushfiq Akanda
  • Alberto Azor Lafarga

Recognition

Memberships of editorial boards and associations

  • Editor in "Advances in Pharmaceutical Technology", Wiley, UK
  • Journal of Nanomedicine and Nanotechnology
  • Pharmaceutica Analytica Acta
  • Pharmaceutical Regulatory Affairs
  • E-Journal of Chemistry
  • International Journal of Nano Studies & Technology
  • The Higher Education Academy (UK)
  • Greek Chemists Association (Greece).

Research / Scholarly interests

Continuous manufacturing via hot melt extrusion (HME)

Medical devices

  • Drug eluting stents for cardiovascular diseases
  • Microneedles for transdermal delivery.

Nanotechnology

  • Development of novel drug delivery systems for cancer imaging and treatment (liposomes, solid lipid nanoparticles, mesoporous silica nanoparticles and conjugated quantum dots).

Consultancy

CIPER undertakes a range of consultancy projects including preformulation, pharmaceutical/nutraceutical feasibility projects and physicochemical characterization

Other

Patents

Method of coating microneedle devices (WO/20110915 ) - 2011.

Key funded projects

  • Innovative MulticOmponent Drug dEsign (IMODE) for enhancing regional strategic advantages in pharmaceutical and biomedical applications. INTERREG IVA "2 Mers Seas Zeeen", 2016, (€880,891) PDF
  • Development of hot melt extruded water insoluble drugs by using co-processed excipients (Fuji Chemicals, Japan, £60,000)
  • Advanced materials and Pharmaceutical Technologies (AMPTEC), INTERREG IVA "2 Mers Seas Zeeen", 2013, (€104,000)
  • Development of a multifunctional stent. (MultiDES). A European project in collaboration with Universities of Lille 1 and Lille 2 (France) funded by INTERREG IVA "2 Mers Seas Zeeen", 2010, (€892,000)

Recent publications

Article

Boateng, Joshua , Hafezi, Forough, Tabriz, Atabak, Douroumis, Dionysios (2023), 3D printed composite dressings loaded with human epidermal growth factor for potential chronic wound healing applications. Elsevier. In: , , , . Elsevier, Journal of Drug Delivery Science and Technology, 86: 104684 . pp. 1-13 ISSN: 1773-2247 (Print), 2588-8943 (Online) (doi: https://doi.org/10.1016/j.jddst.2023.104684).

Ghanizadeh Tabriz, Atabak , Gonot-Munck, Quentin, Baudoux, Arnaud, Garg, Vivek , Farnish, Richard , L.Katsamenis, Orestis , Hui, Ho-Wah , Boersen, Nathan , Roberts, Sandra , Jones, John (2023), 3D printing of personalised Carvedilol tablets using selective laser sintering. MDPI. In: , , , . MDPI, Pharmaceutics, 15: 2230 (9) . pp. 1-19 1999-4923 (Online) (doi: https://doi.org/10.3390/pharmaceutics15092230).

Ghanizadeh Tabriz, Atabak , Viegas, Beatriz, Okereke, Michael, Uddin, Md Jasim , Arribas Lopez, Elena , Zand Fard, Nazanin , Ranatunga, Medhavi , Getti, Giulia , Douroumis, Dionysios (2022), Evaluation of 3D printability and biocompatibility of microfluidic resin for fabrication of solid microneedles. MDPI. In: , , , . MDPI, Micromachines, 13: 1368 . pp. 1-16 2072-666X (Online) (doi: https://doi.org/10.3390/mi13091368).

Junqueira, Laura Andrade , Ghanizadeh Tabriz, Atabak, Raposo, Francisco José, Carobini, Luana Rocha , Vaz, Urias Pardócimo , Brandão, Marcos Antônio Fernandes , Douroumis, Dionysios , Raposo, Nádia Rezende Barbosa (2022), Coupling of fused deposition modeling and inkjet printing to produce drug loaded 3D printed tablets. MDPI. In: , , , . MDPI, Pharmaceutics, 14: 159 (1) 1999-4923 (Online) (doi: https://doi.org/10.3390/pharmaceutics14010159).

Economidou, Sophia N. and , Douroumis, Dionysios (2021), 3D printing as a transformative tool for microneedle systems: recent advances, manufacturing considerations and market potential. Elsevier. In: , , , . Elsevier, Advanced Drug Delivery Reviews, 173 . pp. 60-69 ISSN: 0169-409X (Print), 1872-8294 (Online) (doi: https://doi.org/10.1016/j.addr.2021.03.007).

Akanda, Md Mushfiq , Getti, Giulia, Nandi, Uttom, Mithu, Md Sadeque Hossain , Douroumis, Dionysios (2021), Bioconjugated solid lipid nanoparticles (SLNs) for targeted prostate cancer therapy. Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics, 599: 120416 ISSN: 0378-5173 (Print), (doi: https://doi.org/10.1016/j.ijpharm.2021.120416).

Akanda, Mushfiq , Getti, Giulia, Nandi, Uttom, Sadeque Mithu, Md , Douroumis, Dionysios (2021), Bioconjugated solid lipid nanoparticles (SLNs) for targeted prostate cancer therapy. Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics, 599: 120416 ISSN: 0378-5173 (Print), (doi: https://doi.org/10.1016/j.ijpharm.2021.120416).

Economidou, Sophia , Pissinato Pere, Cristiane, Okereke, Michael, Douroumis, Dionysios (2021), Optimisation of design and manufacturing parameters of 3D printed solid microneedles for improved strength, sharpness, and drug delivery. MDPI AG. In: , , , . MDPI AG, Micromachines, 12 (2) ISSN: 2072-666X (Print), (doi: https://doi.org/10.3390/mi12020117).

Economidou, Sophia N. , Uddin, Md. Jasim, Marques, Manuel J., Douroumis, Dennis , Ting Sow, Wan , Li, Huaqiong , Reid, Andrew , Windmill, James F.C. , Podoleanu, Adrian (2020), A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalised transdermal drug delivery. Elsevier. In: , , , . Elsevier, Additive Manufacturing, 38: 101815 ISSN: 2214-7810 (Print), 2214-8604 (Online) (doi: https://doi.org/10.1016/j.addma.2020.101815).

Ghanizadeh Tabriz, Atabak , Nandi, Uttom, Hurt, Andrew, Hui, Ho-Wah , Karki, Shyam , Gong, Yuchuan , Kumar, Sumit , Douroumis, Dionysios (2020), 3D printed bilayer tablet with dual controlled drug release for tuberculosis treatment. Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics, 593: 120147 ISSN: 0378-5173 (Print), (doi: https://doi.org/10.1016/j.ijpharm.2020.120147).

Nandi, Uttom , Trivedi, Vivek, Douroumis, Dennis, Mendham, Andrew P. , Coleman, Nichola J. (2020), Layered Silicate-Alginate Composite Particles for the pH-Mediated Release of Theophylline. MDPI. In: , , , . MDPI, Pharmaceuticals, 13: 182 (8) 1424-8247 (Online) (doi: https://doi.org/10.3390/ph13080182).

Hafezi, Forough , Shorter, Susan, Tabriz, Atabak Ghanizadeh, Hurt, Andrew P. , Elmes, Victoria , Boateng, Joshua , Douroumis, Dionysios (2020), Bioprinting and preliminary testing of highly reproducible novel bioink for potential skin regeneration. MDPI. In: , , , . MDPI, Pharmaceutics, 12: 550 (6) ISSN: 1999-4923 (Print), 1999-4923 (Online) (doi: https://doi.org/10.3390/pharmaceutics12060550).

Mithu, Sadeque Hossain , Ross, Steven A., Alexander, Bruce D., Douroumis, Dennis (2019), Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Green Chemistry, 22 (2) . pp. 540-549 ISSN: 1463-9262 (Print), 1463-9270 (Online) (doi: https://doi.org/10.1039/C9GC03528A).

Economidou, Sophia N. , Pissinato Pere, Cristiane Patricia, Reid, Andrew, Uddin, Jasim Md. , Windmill, James F.C. , Lamprou, Dimitrios A. , Douroumis, Dennis (2019), 3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery. Elsevier. In: , , , . Elsevier, Materials Science and Engineering C, 102 . pp. 743-755 ISSN: 0928-4931 (Print), (doi: https://doi.org/10.1016/j.msec.2019.04.063).

Boateng, Joshua , Hafezi, Forough, Scoutaris, Nikolaos, Douroumis, Dennis (2019), 3D printed chitosan dressing crosslinked with genipin for potential healing of chronic wounds. Elsevier B.V.. In: , , , . Elsevier B.V., International Journal of Pharmaceutics, 560 . pp. 406-415 ISSN: 0378-5173 (Print), 1873-3476 (Online) (doi: https://doi.org/10.1016/j.ijpharm.2019.02.020).

Loughrill, Emma , Thompson, Sharon, Owusu-Ware, Samuel K., Snowden, Martin J. , Douroumis, Dennis , Zand Fard, Nazanin (2019), Controlled release of microencapsulated docosahexaenoic acid (DHA) by spray–drying processing. Elsevier. In: , , , . Elsevier, Food Chemistry, 286 . pp. 368-375 ISSN: 0308-8146 (Print), (doi: https://doi.org/10.1016/j.foodchem.2019.01.121).

Ross, Steven A. , Ward, Adam, Basford, Pat, McAllister, Mark , Douroumis, Dennis (2018), Coprocessing of pharmaceutical cocrystals for high quality and enhanced physicochemical stability. American Chemical Society (ACS). In: , , , . American Chemical Society (ACS), Crystal Growth & Design, 19 (2) . pp. 876-888 ISSN: 1528-7483 (Print), 1528-7505 (Online) (doi: https://doi.org/10.1021/acs.cgd.8b01440).

Pere, Cristiane Patricia Pissinato , Economidou, Sophia N., Lall, Gurprit, Ziraud, Clémentine , Boateng, Joshua , Alexander, Bruce D. , Lamprou, Dimitrios A. , Douroumis, Dennis (2018), 3D printed microneedles for insulin skin delivery. Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics, 544 (2) . pp. 425-432 ISSN: 0378-5173 (Print), 1873-3476 (Online) (doi: https://doi.org/10.1016/j.ijpharm.2018.03.031).

Scoutaris, Nikolaos , Ross, Steven A., Douroumis, Dennis (2018), 3D printed "Starmix" drug loaded dosage forms for paediatric applications. Springer Verlag. In: , , , . Springer Verlag, Pharmaceutical Research, 35 ISSN: 0724-8741 (Print), 1573-904X (Online) (doi: ).

Scoutaris, Nicolaos , Malamatari, Maria, Letellier, Adrien, Douroumis, Dennis (2017), Jet dispensing of multi-layered films for the co-delivery of three antihypertensive agents. Springer US. In: , , , . Springer US, Drug Delivery and Translational Research, 8 (1) . pp. 32-42 ISSN: 2190-393X (Print), 2190-3948 (Online) (doi: https://doi.org/10.1007/s13346-017-0430-3).

Maniruzzaman, Mohammed , Ross, Steven A., Dey, Tumpa, Nair, Arun , Snowden, Martin J. , Douroumis, Dennis (2017), A quality by design (QbD) twin–screw extrusion wet granulation approach for processing water insoluble drugs. Elsevier B.V.. In: , , , . Elsevier B.V., International Journal of Pharmaceutics, 526 (1-2) . pp. 496-505 ISSN: 0378-5173 (Print), (doi: https://doi.org/10.1016/j.ijpharm.2017.05.020) NB Item availability restricted.

Maniruzzaman, M. , Ross, S.A., Islam, M.T, Scoutaris, N. , Nair, A. , Douroumis, Dennis (2017), Increased dissolution rates of tranilast solid dispersions extruded with inorganic excipients. Taylor & Francis. In: , , , . Taylor & Francis, Drug Development and Industrial Pharmacy, 43 (6) . pp. 947-957 ISSN: 0363-9045 (Print), 1520-5762 (Online) (doi: https://doi.org/10.1080/03639045.2017.1287716) NB Item availability restricted.

Maniruzzaman, Mohammed , Farias, Smirna, Slipper, Ian J., Boateng, Joshua S. , Chowdhry, Babur Z. , Nair, Arun , Douroumis, Dennis (2016), Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing. Wiley. In: , , , . Wiley, Journal of Pharmacy and Pharmacology, 68 (7) . pp. 890-900 ISSN: 0022-3573 (Print), 2042-7158 (Online) (doi: http://doi.org/10.1111/jphp.12569) NB Item availability restricted.

Scoutaris, Nikolaos , Chai, Feng, Blandine, Maurel, Sobocinski, Jonathan , Zhao, Min , Moffat, Jonathan G. , Craig, Duncan Q. , Martel, Bernard , Blanchemain, Nicolas , Douroumis, Dennis (2016), Development and biological evaluation of Iinkjet printed drug coatings on intravascular stent. American Chemical Society. In: , , , . American Chemical Society, Molecular Pharmaceutics, 13 (1) . pp. 125-133 ISSN: 1543-8384 (Print), 1543-8392 (Online) (doi: http://dx.doi.org/10.1021/acs.molpharmaceut.5b00570).

Book section

Tabriz, Atabak Ghanizadeh , Douroumis, Dennis, Boateng, Joshua (2019), 3D printed scaffolds for wound healing and tissue regeneration. Wiley. In: , , In: Joshua Boateng (ed.), Therapeutic Dressings and Wound Healing Applications. Wiley, (1st) . pp. 385-398 . ISBN: 9781119433262 (doi: https://www.wiley.com/en-gb/Therapeutic+Dressings+and+Wound+Healing+Applications-p-9781119433262).

Patent

Douroumis, Dionysios , Bradley, Michael, Scoutaris, Nikolaos (2017), STENT WO 2016116748 A1. In: , , , . , (doi: ).

View all publications