Our current projects involve the utility of metabonomics in the study of cardiovascular disease, diabetes and exercise, nutrition and obesity.

We welcome suggestions for new projects, collaborations and consultancy.

OmniHeart Metabonomics Study

This project focuses on metabolic phenotyping using high-resolution spectroscopy of urine samples from the OmniHeart study.  The global aim of this project is to identify the impact of different dietary interventions on the urinary metabolic phenotypes and to investigate specific urinary biomarkers associated with blood pressure and other cardiovascular disease risk factors, using the metabonomics-wide-association approach.

This project is collaboration between Medway School of Pharmacy, Imperial College London and The Johns Hopkins University.  Ruey Leng is the lead of this MRC-funded project. This project is supported by a post-doc, Xin Zao, and a part-time technician, Viktorija Kuziene.

Diabetes and Exercise Metabonomics and Pharmacometabonomics Study

This project focuses on the metabolic profiling of urine and plasma samples from diabetic patients. The aim of the project is to evaluate and predict the efficacy of various combined drug and exercise regimes on the clinical outcomes for these patients.

This project is led by Jeremy Everett in collaboration Professor Stefano Balducci and Professor Silvano Zanuso at the University of Rome, Italy, working with Ruey Leng Loo, Frank Pullen and Dorsa Varshavi.