Applications Faculty of Engineering & Science

Below is a brief overview of the major mass spectrometric applications we currently support.

Chemistry, drug discovery, drug metabolism, pharmacokinetics etc.:

  • Accurate molecular weight measurements; confirm and elucidate molecular structure and purity, identification of unknowns
  • Quantitative analysis of drugs and metabolites in a variety of matrices including blood and urine
  • Separation of complex mixtures using hyphenated techniques e.g. ion mobility mass spectrometry, gas chromatography, ultra-high pressure liquid chromatography, direct analysis in real-time ionisation.

Biology, chemical biology, biotechnology etc. e.g. proteins, peptides, oligonucleotides:

  • Accurate molecular weight measurements; confirm molecular structure and purity, detect post-translational modifications, calculate number of disulphide bridges
  • Rapid reaction monitoring; monitor enzyme reactions, chemical modifications or protein digestion
  • Amino acid sequencing; confirm amino acid sequence, de novo characterisation of peptides, identify proteins by database searching from protein digest
  • Oligonucleotide sequencing; characterise or quality control of oligonucleotides
  • Monitor protein structure; monitor protein-ligand complex formation under physiological conditions, macromolecular structure determination.

Environmental, geological, nutrition, food science etc.:

  • Separation of complex mixtures to confirm and quantify using database matching and retention time locking
  • Quantitative analysis of contaminants in water, food, soil etc.
  • Fingerprinting of oil types and measurement of oil composition.