Cellular and Molecular Pathology (Level 5)

Module summary

Module code: ANAT1100
Level: 5
Credits: 15
School: Engineering and Science
Department: Science
Module Coordinator(s): Laura Pellatt

Specification

Aims

• To review the histo/cytological classification of tissues and apply this to diagnosis of disease by the examination of cells and tissues;
• To examine the mechanisms, practices and pitfalls of cellular pathology techniques;
• To develop an understanding of the role of cellular pathology in clinical diagnosis;
• To illustrate the interaction of pathological agents, both acquired and congenital with cellular and sub-cellular structures;
• To describe the mechanisms of disease produced as a result of such interactions;
• To relate the clinical presentation of disease to its cellular and molecular basis.

Learning outcomes

On successful completion of this module a student will be able to:
1. Discuss in depth the overall principles and practices of histopathological and cytopathological investigations
2. Discuss the constraints placed on tissue examination by biopsy and histological preparation procedures
3. Discuss the rationale of population screening programmes with reference to malignant disease.
4. Evaluate the mechanisms and molecular basis of cellular pathology techniques.
5. Discuss the aetiology of disease, whether as a result of external agents or internal malfunction.
6. Discuss current understanding of the changes in cellular structure and/or function, which occur as a result of disease.
7. Describe the cellular basis of major clinical examples of disease e.g. neoplasia, metabolic defects, infection, atheroma.

Indicative content

Cellular Pathology in clinicial diagnosis
Tissue sampling techniques
Tissue processing and microtomy
Cytology and cytopathology
Staining techniques
Specialised stains
Immunohistochemistry
Specialised microscopy
Diagnostic and autopsy pathology
Histopathology – malignancy, infections

Teaching and learning activity

The module will be taught largely through lectures and laboratory-based work. The principles will be explained in the lectures, and the laboratory work will make practical use of the principles. Development of group-working and presentational skills will also take place in the laboratory work.

The extensive practical programme of study will vary in style according to the particular part of the Indicative Content being supported.

Assessment

Practical & Report: 50% weighting, 40% pass mark. Learning Outcomes: 3, 5, 6, 7. Word Length: 1500 words.

Case Study: 50% weighting, 40% pass mark. Learning Outcomes: 1 - 2, 4 - 7.

Formative Assessment: Online tests allow 2 attempts- 1st result returned with feedback (Formative) before summative 2nd attempt.