Cell Biology and Immunology

Module summary

Module code: BIOL1048
Level: 5
Credits: 15
School: Engineering and Science
Department: Science
Module Coordinator(s): Nyree Myatt

Specification

Aims

1. To introduce the concepts in immunology, examine the innate adaptive defence mechanisms of the immune response against
infectious agents
2. To explore the mechanisms of activation and regulation and the consequences of adverse immune responses
3. To develop a greater understanding of the regulation of the cell cycle and cell death, and explore the differentiation and
arrangement of cells in the context organ formation during development.
4. To develop a deeper understanding of the function of specific organelles in specialised cell functions.

Learning outcomes

On successful completion of this course a student will be able to:

1 Describe the structure and function of the critical components of the immune system and identify different lymphoid tissues, cells and cytokines important for an immune response.
2 Discuss the types of immune response, triggering mechanisms, physiological processes and regulation involved in the immune response.
3 Classify different hypersensitivity responses, immunodeficient states, autoimmune and other immune-compromised states.
4 Identify the stages in and explain the sequence of embryonic development and explain the cellular and molecular mechanisms of cell growth, apoptosis, and fertilisation.
5 Discuss the regulation of the cell cycle and the role of specific cell organelles in relation to specific functions.

Indicative content

The innate and adaptive immune response. Inflammation, its development and regulation. Primary and secondary lymphoid organs, lymphopoiesis, cellular and humoral components. Nutrition in relation to immune function. Classification of hypersensitivity, autoimmune reactions and immunodeficiencies. The cell cycle and cellular, molecular and biochemical aspects of fertilisation and early embryogenesis (e.g. blastulation, gastrulation). Differentiation of specific tissues and organs; pattern formation. molecular mechanism of apoptosis and the role of the mitochondria; cell to cell communication, adhesion and motility. Endocytosis and membrane trafficking.


Skills Learning Outcomes:

1. Communicate about their subject appropriately using a range of formats, information gathering systems, and present data
effectively;
2. Write scientifically using appropriate nomenclature and referencing systems.
3. Manage time effectively in relation to planning, submitting assessments, and design, plan, conduct and report on investigations;
4. Be adaptable, flexible, and effective in approaches to study and work, and undertake investigations in a responsible, safe and
ethical manner;

Teaching and learning activity

This course will consist mainly of lectures/tutorials, explaining basic concepts. Students will carry out exercises in tutorial sessions that will extend and develop the learning that occurs in lectures.

Assessment

Case study - 25%
LOs - 1, 2, 3
Words 1500-2000
Essay / case study evaluating the central concepts

Practical - 25%
LOs - 2
A practical write up relevant to theoretical knowledge of the course


Exam - 50%
LOs - ALL
2 Hours

40% overall Pass mark