Dr Milan Antonijevic

Dr Milan Antonijevic BSc, PhD, FRSC, FHEA, MAPS

Associate Professor, Pharmaceutical Analysis

Key details

Dr Milan D Antonijevic
BSc, PhD, FRSC, FHEA, MAPS

Associate Professor, Pharmaceutical Analysis


Dr Milan Antonijevic obtained a BSc Hons in chemistry from the School of Chemistry, University of Belgrade, Serbia in 1997. He then spent just over four years working in the quality control department (physico-chemical characterisation) of Hemofarm, the leading pharmaceutical company in Serbia. His next career step involved a move to the UK and the continuation of his education.

Dr Antonijevic studied pharmaceutical materials science under the supervision of Dr Susan A Barker and Professor Duncan Q M Craig. He was awarded a PhD at the School of Pharmacy, Queen's University Belfast, in 2005.

His first faculty post was at the School of Chemical Sciences and Pharmacy, University of East Anglia, 2004 as a senior demonstrator. His first permanent faculty post as a lecturer at the School of Science, University of Greenwich, started in 2006, progressing to senior lecturer and programme Leader for BSc Hons Chemistry in 2008 and subsequently becoming principal lecturer and programme leader for MSc Pharmaceutical Science in 2010.

Dr Antonijevic uses thermal analytical techniques, specifically, thermally stimulated current (TSC) spectroscopy to study pharmaceutically important molecules. His particular interest lies in monitoring phase changes of active principles, excipients and their interactions. Information obtained is used to develop optimal dosage form. Additional projects involve development of methods that can be used to predict the stability, photodegradation pathways and kinetics of photo degradation of drug in both crystalline and amorphous form.

Responsibilities within the university

Programme Leader

  • MSc in Pharmaceutical Sciences
  • MSc by Research

Module Co-ordinator

  • Analytical Chemistry
  • Practical & Professional Skills
  • Analytical Methods & QA/QC Principles
  • MSc Pharmaceutical Science projects

Module participation

  • Analytical Chemistry
  • Practical & Professional Skills
  • Further Physical Chemistry
  • Instrumental Analysis
  • Pharmaceutical Analysis
  • Advanced Practical Skills and Research Methodology
  • Special Topics in Chemistry
  • Modern Pharmaceutical Technologies and Process Engineering
  • Analytical Methods and QA/QC principles
  • MSc Pharmaceutical Science research project

Awards

Early Career Research Excellence Award, University of Greenwich, 2010/2011

£5000 towards research activities

Presentation won a prize for the best presentation in drug analysis and quality control section of the official programme of the congress. Milan D. Antonijevic, "Amorphous materials: pharmaceutical importance, detection and characterisation", 5th Congress of Pharmacists of Serbia, Belgrade, 13th-17th October 2010

Best Poster of the 2010 Annual Conference EAFP

Jelena Parojcic, Mira Zecevic, Deirdre D'Arcy, Milan Antonijevic, Simon Walker, Mila Bozic, Stane Srcic. 'Qualified person learning programme development: An E-xample of the Tempus Joint Project Activity', European Association of Faculties of Pharmacy - 2010 Annual Conference - Jun, 24th to 26th, 2010, Catania, Italy

Recognition

  • Fellow of the Royal Society of Chemistry (FRSC)
  • Member of the Academy of Pharmaceutical Sciences (MAPS)
  • Fellow of the Higher Education Authority (FHEA)
  • Committee member of the Thermal Method Group (Royal Society of Chemistry)

Research / Scholarly interests

As an emerging discipline, pharmaceutical materials science correlates physical properties of active compounds and pharmaceutical ingredients with the performance of the finished dosage product.

Small molecules of pharmaceutical interest can exist in many different forms called morphs, which have different degrees of order at the atomic level. Detection, characterisation and quantification of amorphous, polymorphs and pseudopolymorhs have been recent subjects of research globally.

Drugs in the amorphous or non-crystalline form often have better bioavailability, which can be due to the better dissolution rate compared with their crystalline counterparts. Naturally, the less ordered (amorphous) state does tend to convert into a more stable (crystalline) state of matter. Therefore the efficiency and stability of the final pharmaceutical product often depend on using the correct crystalline or amorphous form of a drug or excipient.

Research in this area focuses on studies of the glass transition phenomenon. Glass-forming materials can be analysed with techniques such as thermal analytical methods, calorimetric methods, crystallography and nuclear magnetic resonance. Although these techniques provide important information about the phase transition processes, new techniques are frequently being used to expand knowledge of existing glass transition processes and to identify previously undetected glass transitions.

Current research focuses on the use and development of thermal analytical techniques. An example is thermally stimulated current spectroscopy (TSC) for the characterisation and design of drugs and drug delivery systems. These include amorphous and polymorphic drugs and mainly polymeric delivery systems.

In respect of glass-forming materials, interest lies in understanding the cooperative rearrangements within the system. These can be studied by assessing the distribution of the relaxation process, using relaxation map analysis. In addition, thermal analytical methods have been used to investigate correlation between empirical parameters of the glass-forming systems such as the fragility index and its chemical structure.

The interest in physico-chemical properties of drugs and dosage forms includes research of stability assessments and prediction. Of particular interest is exploring kinetics and degradation pathways of light-sensitive pharmaceutical compounds. Recent research has therefore investigated the problems of characterising amorphous materials and understanding stability of pharmaceutical active compounds and end products.

This has led to considerable expertise in the following analytical techniques:

  • Ultra-violet-visible spectroscopy (UV/VIS)
  • Infra-red spectroscopy (IR)
  • High-performance liquid chromatography (HPLC)
  • HPLC/mass spectroscopy (HPLC/MS)
  • Thermogravimetric analysis (TGA)
  • Differential scanning calorimetry (DSC)
  • Modulated temperature DSC, hot stage microscopy (HSM)
  • Thermally stimulated current spectroscopy (TSC)

Key funded projects

Consultancy project: "Exploring various novel and existing physico-chemical testing procedures to identify and map characteristics of topically applied emollients for optimum clinical effectiveness and user acceptance"
  • Project duration: 15.01.2019 – 14.04.2019
  • Funder: Dermal Laboratories Ltd
  • Grant: £18,750.00
Industrial project: "Ex vivo human skin investigation of physical attributes of novel and commercially available topical formulations."
  • Project duration: 01.12.2018 to 01.12.2023
  • Funder: Dermal Laboratories Ltd
  • Grant: £175,000.00
Consultancy project: "Exploring various novel and existing physico-chemical testing procedures to identify and map characteristics of topically applied emollients for optimum clinical effectiveness and user acceptance."
  • Project duration: 15.01.2018 – 15.01.2019
  • Funder: Dermal Laboratories Ltd
  • Grant: £75,000.00
Industrial project: "Ex vivo human skin investigation of physical attributes of novel and commercially available topical formulations"
  • Project duration: 01.12.2016 to 01.12.2018
  • Funder: Dermal Laboratories Ltd
  • Grant: £70,000.00
Erasmus + project - 573885-EPP-1-2016-1-RS-EPPKA2-CBHE-JP - "ICT networking for overcoming technical and social barriers in instrumental analytical chemistry education"
  • International project, 13 collaborators, 15.10.2016 - 14.10.2019
  • Total value of the project: - € 947,777.00
  • Project website: http://www.netchem.ac.rs/
Consultancy project: "Exploring various novel and existing physico-chemical testing procedures to identify and map characteristics of topically applied emollients for optimum clinical effectiveness and user acceptance"
  • Project duration: 01.08.2016 – 01.08.2017
  • Funder: Dermal Laboratories Ltd
  • Grant: £75,000.00
Consultancy project: "Exploring various novel and existing physico-chemical testing procedures to identify and map characteristics of topically applied emollients for optimum clinical effectiveness and user acceptance"
  • Project duration: 01.08.2015 – 01.08.2016
  • Funder: Dermal Laboratories Ltd
  • Grant: £75,000.00
Industrial project: "Investigations of ex-vivo skin penetration and physical attributes of novel and commercially available topical formulations" 
  • Project duration: 01.12.2014 to 01.12.2016
  • Funder: Dermal Laboratories Ltd
  • Grant: £70,000.00
Tempus IV project - 544543-Tempus-1-2013-1-RS-Tempus-JPCR - "Modernization and harmonization of tourism study programs in Serbia - MHTSPS" 
  • International project, 11 collaborators, 01.12.2013 - 01.12.2016
  • Total value of the project: - € 707,582.97
  • TEMPUS grant - € 661,292.50
  • Project website: http://mhtsps.vpts.edu.rs/
Tempus IV project - 'Modernisation of Post-Graduate Studies in Chemistry and Chemistry Related Programmes - MCHEM'
  • International project, 14 collaborators, 15.10.2010 - 13
  • Total value of the project: - € 813,004.80
  • Tempus grant - € 731,704.40
  • Project website: http://www.tempus-mchem.ac.rs/
Tempus IV project - 'Postgraduate Qualifications in Pharmacy: The Way Forward – PQPharm'
  • International project, 15 collaborators, 15.01.2010 -13
  • Total value of the project: - € 764,290.00
  • TEMPUS grant - € 686,890.00
  • Project website: http://pqpharm.ac.rs/

Recent publications

Article

D'Angelo, Alessandra , Reading, Mike, Antonijevic, Milan (2019), A novel micro-photogrammetric instrument for visualizing in 3D small objects applied to the quantitative study of the dissolution behavior of a pharmaceutical dosage form, AIP Publishing. In: , , , . AIP Publishing, Review of Scientific Instruments ISSN: 0034-6748 (Print), 1089-7623 (Online) (doi: https://doi.org/10.1063/1.5135378) Published NB Item availability restricted.

Abu Fara, Deeb , Dadou, Suha M., Rashid, Iyad, Al-Obeidi, Riman , Antonijevic, Milan D. , Chowdhry, Babur Z. , Badwan, Adnan (2019), A direct compression matrix made from Xanthan gum and low molecular weight chitosan designed to improve compressibility in controlled release tablets, MDPI. In: , , , . MDPI, Pharmaceutics ISSN: 1999-4923 (Print), 1999-4923 (Online) (doi: https://doi.org/10.3390/pharmaceutics11110603) Published NB Item availability restricted.

Najdanović, Slobodan , Petrović, Milica M., Kostić, Miloš M., Mitrović, Jelena Z. , Bojić, Danijela V. , Antonijević, Milan D. , Bojić, Aleksandar Lj. (2019), Electrochemical synthesis and characterization of basic bismuth nitrate [Bi6O5(OH)3](NO3)5·2H2O: a potential highly efficient sorbent for textile reactive dye removal, Springer Netherlands. In: , , , . Springer Netherlands, Research on Chemical Intermediates pp. 661-680 ISSN: 0922-6168 (Print), 1568-5675 (Online) (doi: https://doi.org/10.1007/s11164-019-03983-1) Published NB Item availability restricted.

Owusu-Ware, Samuel K. , Boateng, Joshua S., Chowdhry, Babur Z., Antonijevic, Milan D. (2019), Glassy state molecular mobility and its relationship to the physico-mechanical properties of plasticized hydroxypropyl methylcellulose (HPMC) films, Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics: X ISSN: 0378-5173 (Print), (doi: https://doi.org/10.1016/j.ijpx.2019.100033) Published.

Dadou, Suha M. , El-Barghouthi, Musa I., Antonijevic, Milan D., Chowdhry, Babur Z. , Badwan, Adnan A. (2019), Elucidation of the controlled-release behavior of metoprolol succinate from directly compressed xanthan gum-chitosan polymers: computational and experimental studies, ACS. In: , , , . ACS, ACS Biomaterials Science & Engineering pp. 21-37 ISSN: 2373-9878 (Print), 2373-9878 (Online) (doi: https://doi.org/10.1021/acsbiomaterials.8b01028) Published.

D'Angelo, A. , Edgar, B., Hurt, A. P., Antonijević, M. D. (2018), Physio-chemical characterization of three-component co-amorphous systems generated by a melt-quench method, Springer Netherlands. In: , , , . Springer Netherlands, Journal of Thermal Analysis and Calorimetry pp. 381-390 ISSN: 1388-6150 (Print), 1572-8943 (Online) (doi: https://doi.org/10.1007/s10973-018-7291-y) Published NB Item availability restricted.

Antonijević, M.D. , Owusu-Ware, S., Sanchon-Lopez, B. (2018), Emollient product design: objective measurements of formulation structure, texture and performance, and subjective assessments of user acceptability, Wiley. In: , , , . Wiley, Clinical and Experimental Dermatology pp. 423-429 ISSN: 0307-6938 (Print), 1365-2230 (Online) (doi: https://doi.org/10.1111/ced.13364) Published NB Item availability restricted.

Reading, Michael , Ghori, Muhammad, Brown, Robert, Fleming, Leigh , Antonijevic, Milan , Grandy, David B. , Hourston, Douglas , Song, Mo , Conway, Barbara R. (2017), Chemical imaging by dissolution analysis (CIDA): Localized kinetics of dissolution behavior to provide 2D chemical mapping and tomographic imaging on a nanoscale, American Chemical Society. In: , , , . American Chemical Society, Analytical Chemistry pp. 5882-5890 ISSN: 0003-2700 (Print), 1520-6882 (Online) (doi: https://doi.org/10.1021/acs.analchem.7b00202) Published NB Item availability restricted.

Conference item

Antonijevic, Milan and , (2018), Development and characterisation of a pharmaceutically important multi-component co-amorphous systems using thermal analysis, In: 12th European Symposium on Thermal Analysis and Calorimetry, 27-30 August 2018, Brasov, Romania , . , (doi: ) Unpublished.