Biomedical Science Research Group

Biomedical Science Research Group

A key focus of research within the Biomedical Science Group is the development of our understanding of the pathogenic mechanisms of infectious agents and the impact these infectious agents play on the host immune response.

Research activity

About us

A key focus of research within the Biomedical Science Research Group is the development of our understanding of the pathogenic mechanisms of infectious agents and the impact these infectious agents play on the host immune response.

This interest also extends to the molecular pathology of many other conditions such as cancer. One particular interest is the effect on disease manifestation and burden on the host organism. Our investigation aims to clarify the cytokine expression profiles in response to challenge, apoptotic pathways, circadian rhythms and infection, as well as the investigation of the cellular trafficking pathways and strategies to modulate both the life cycle and immunological responses to infectious agents for therapeutic intervention. Our work here principally focuses on bacterial virulence factors and protozoal organisms (e.g., Leishmania spp.).

A second strand of investigation is the development and delivery of interventions based upon siRNA and antisense modalities. These are particularly relevant to the eradication of viral infection and the management of a variety of neoplasia.

Recent publications

Article

Walsh, Yvonne , Leach, Michael, Veale, Emma, Mathie, Alistair (2021), Block of TREK and TRESK K2P channels by lamotrigine and two derivatives sipatrigine, and CEN-092. Elsevier. In: , , , . Elsevier, Biochemistry and Biophysics Reports, 26: 101021 ISSN: 2405-5808 (Print), (doi: https://doi.org/10.1016/j.bbrep.2021.101021).

Getti, G. T. M and , Poole, P. L. (2019), Allicin causes fragmentation of the peptidoglycan coat in Staphylococcus aureus by effecting synthesis and aiding hydrolysis: a determination by MALDI-TOF mass spectrometry on whole cells. Microbiology Society. In: , , , . Microbiology Society, Journal of Medical Microbiology, 68 (4) . pp. 667-677 ISSN: 0022-2615 (Print), 1473-5644 (Online) (doi: https://doi.org/10.1099/jmm.0.000950).

Feron, Benedita Kaç Labbé and , Richardson, Simon Clifford Wainwright (2018), The delivery of personalised, precision medicines via synthetic proteins. Bentham Science Publishers. In: , , , . Bentham Science Publishers, Drug Delivery Letters, 9 (1) . pp. 79-88 ISSN: 2210-3031 (Print), 2210-304X (Online) (doi: https://doi.org/10.2174/2210303109666181224115722).

Shorter, Susan , Pettit, Marie W., Dyer, Paul D.R., Coakley-Youngs, J. Emma , Gorringe-Pattrick, Monique A. M. , El-Daher, Samer , Richardson, Simon (2017), Green Fluorescent Protein (GFP): is seeing believing and is that enough?. Taylor & Francis. In: , , , . Taylor & Francis, Journal of Drug Targeting, 25 (9-10) . pp. 809-817 ISSN: 1061-186X (Print), 1029-2330 (Online) (doi: https://doi.org/10.1080/1061186X.2017.1358725).