Centre for Innovation in Process Engineering and Research
The Centre specialises on the design of novel manufacturing processes, engineering of drug delivery systems, fabrication of medical devices and bioprinting. The Centre has established a world-wide reputation through industrial collaborations (including Celgene, Pfizer, TEVA, GW Pharma, Johnson Matthey, Fuji Chemicals).
About us
- We design continuous pharmaceutical processes including hot melt extrusion, granulation. Continuous processing emphasises on the development of solid dispersions, cocrystals and salts.
- Advance 3D printing technologies for the fabrication of transdermal microneedles and bioabsorbable drug eluting stents
- Bioprinting of cell – laden structures for wound healing applications
- We engineer active targeted nano drug delivery systems for cancer treatment using bioconjugated solid lipid or mesoporous silica nanoparticles
- Areas of expertise included paediatric formulations, taste masked ODT dosage forms, controlled, sustained and immediate release (tablets, capsules, films)
- We use advance characterisation techniques such as PAT tools (e.g. NIR probes), X-ray photoelectron spectroscopy, optical coherence technology, isothermal titration calorimetry, confocal Raman spectroscopy and micro-tomography.
Related research
Explore the university's other research in this discipline.
Chemistry
Chemistry research at Greenwich has a strong biological, medicinal and synthetic theme, and its application into pharmaceutical and materials sciences disciplines.
Recent publications
Article
Junqueira, Laura Andrade , Ghanizadeh Tabriz, Atabak, Raposo, Francisco José, Carobini, Luana Rocha , Vaz, Urias Pardócimo , Brandão, Marcos Antônio Fernandes , Douroumis, Dionysios , Raposo, Nádia Rezende Barbosa (2022), Coupling of fused deposition modeling and inkjet printing to produce drug loaded 3D printed tablets. MDPI. In: , , , . MDPI, Pharmaceutics, 14: 159 (1) 1999-4923 (Online) (doi: https://doi.org/10.3390/pharmaceutics14010159).
Akanda, Md Mushfiq , Getti, Giulia, Nandi, Uttom, Mithu, Md Sadeque Hossain , Douroumis, Dionysios (2021), Bioconjugated solid lipid nanoparticles (SLNs) for targeted prostate cancer therapy. Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics, 599: 120416 ISSN: 0378-5173 (Print), (doi: https://doi.org/10.1016/j.ijpharm.2021.120416).
Economidou, Sophia , Pissinato Pere, Cristiane, Okereke, Michael, Douroumis, Dionysios (2021), Optimisation of design and manufacturing parameters of 3D printed solid microneedles for improved strength, sharpness, and drug delivery. MDPI AG. In: , , , . MDPI AG, Micromachines, 12 (2) ISSN: 2072-666X (Print), (doi: https://doi.org/10.3390/mi12020117).
Economidou, Sophia N. , Uddin, Md. Jasim, Marques, Manuel J., Douroumis, Dennis , Ting Sow, Wan , Li, Huaqiong , Reid, Andrew , Windmill, James F.C. , Podoleanu, Adrian (2020), A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalised transdermal drug delivery. Elsevier. In: , , , . Elsevier, Additive Manufacturing, 38: 101815 ISSN: 2214-7810 (Print), 2214-8604 (Online) (doi: https://doi.org/10.1016/j.addma.2020.101815).
Ghanizadeh Tabriz, Atabak , Nandi, Uttom, Hurt, Andrew, Hui, Ho-Wah , Karki, Shyam , Gong, Yuchuan , Kumar, Sumit , Douroumis, Dionysios (2020), 3D printed bilayer tablet with dual controlled drug release for tuberculosis treatment. Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics, 593: 120147 ISSN: 0378-5173 (Print), (doi: https://doi.org/10.1016/j.ijpharm.2020.120147).
Hafezi, Forough , Shorter, Susan, Tabriz, Atabak Ghanizadeh, Hurt, Andrew P. , Elmes, Victoria , Boateng, Joshua , Douroumis, Dionysios (2020), Bioprinting and preliminary testing of highly reproducible novel bioink for potential skin regeneration. MDPI. In: , , , . MDPI, Pharmaceutics, 12: 550 (6) ISSN: 1999-4923 (Print), 1999-4923 (Online) (doi: https://doi.org/10.3390/pharmaceutics12060550).
Mithu, Sadeque Hossain , Ross, Steven A., Alexander, Bruce D., Douroumis, Dennis (2019), Solid state thermomechanical engineering of high-quality pharmaceutical salts via solvent free continuous processing. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Green Chemistry, 22 (2) . pp. 540-549 ISSN: 1463-9262 (Print), 1463-9270 (Online) (doi: https://doi.org/10.1039/C9GC03528A).
Economidou, Sophia N. , Pissinato Pere, Cristiane Patricia, Reid, Andrew, Uddin, Jasim Md. , Windmill, James F.C. , Lamprou, Dimitrios A. , Douroumis, Dennis (2019), 3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery. Elsevier. In: , , , . Elsevier, Materials Science and Engineering C, 102 . pp. 743-755 ISSN: 0928-4931 (Print), (doi: https://doi.org/10.1016/j.msec.2019.04.063).
Scoutaris, Nikolaos , Ross, Steven A., Douroumis, Dennis (2018), 3D printed "Starmix" drug loaded dosage forms for paediatric applications. Springer Verlag. In: , , , . Springer Verlag, Pharmaceutical Research, 35 ISSN: 0724-8741 (Print), 1573-904X (Online) (doi: ).