Pharmaceutical and Medicinal Science Research Group

Pharmaceutical and Medicinal Science Research Group

The group works on the development of novel therapies for various applications such as anticancer delivery and wound healing using advanced technologies to enhance efficacy and reduce risk to patients.

Research activity

About us

We create new methodologies for the synthesis of biologically active compounds and have the expertise for designing novel formulations and delivery mechanisms that can stabilize, carry and deliver drugs to the required site within the recipient.

Technologies at our disposal include the manufacture of pharmaceutical co-crystals embedded in extruded structures (e.g. films, medical implants) either by Hot Melt Extrusion or 3D printing. We are also involved in process engineering using green technologies such as continuous extrusion granulation, supercritical fluid extraction and freeze –drying.

Related research

Explore the university's other research in this discipline.

Chemistry


Chemistry research at Greenwich has a strong biological, medicinal and synthetic theme, and its application into pharmaceutical and materials sciences disciplines.

Recent publications

Article

Devonport, Jack , Sully, Lauren, Boudalis, Athanassios K., Hassell-Hart, Storm , Leech, Matthew C. , Lam, Kevin , Abdul-Sada, Alaa , Tizzard, Graham J. , Coles, Simon J. , Spencer Evans, John (2021), Room temperature Cu(II) radical-triggered Alkyne C−H activation. American Chemical Society. In: , , , . American Chemical Society, Journal of the American Chemical Society AU ISSN: 2691-3704 (Print), 2691-3704 (Online) (doi: https://doi.org/10.1021/jacsau.1c00310).

Shokry, Dina S. , Waters, Laura J., Parkes, Gareth M.B., Mitchell, John C. (2019), Prediction of human intestinal absorption using micellar liquid chromatography with an aminopropyl stationary phase. Wiley. In: , , , . Wiley, Biomedical Chromatography, 33: e4515 (7) ISSN: 0269-3879 (Print), 1099-0801 (Online) (doi: https://doi.org/10.1002/bmc.4515).

Shokry, Dina S. , Waters, Laura J., Parkes, Gareth M.B., Mitchell, John C. , Snowden, Martin J. (2018), Formation of a bile salt-drug hydrogel to predict human intestinal absorption. Elsevier. In: , , , . Elsevier, Journal of Pharmaceutical Sciences, 108 (1) . pp. 279-287 ISSN: 0022-3549 (Print), 1520-6017 (Online) (doi: https://doi.org/10.1016/j.xphs.2018.10.005).

Shokry, Dina S. , Waters, Laura J., Parkes, Gareth M. B., Mitchell, John C. (2018), Incorporating physiologically relevant mobile phases in micellar liquid chromatography for the prediction of human intestinal absorption. Wiley. In: , , , . Wiley, Biomedical Chromatography, 32: e4351 (12) ISSN: 0269-3879 (Print), 1099-0801 (Online) (doi: https://doi.org/10.1002/bmc.4351).

Minicone, Fabrizio , Attrill, Robin, Hodgson, Michael, Wheelhouse, Katherine , Dobbs, Adrian (2018), First total synthesis and structural confirmation of C13-Butylrubber Oligomers. Wiley. In: , , , . Wiley, European Journal of Organic Chemistry, 2018 (25) . pp. 3271-3275 ISSN: 1434-193X (Print), 1099-0690 (Online) (doi: https://doi.org/10.1002/ejoc.201800937).

Waters, Laura J. , Finch, Catherine V., Bhuiyan, A.K.M. Mehedi H., Hemming, Karl , Mitchell, John C. (2017), Effect of plasma surface treatment of poly (dimethylsiloxane) on the permeation of pharmaceutical compounds. Elsevier. In: , , , . Elsevier, Journal of Pharmaceutical Analysis, 7 (5) . pp. 338-342 ISSN: 2095-1779 (Print), (doi: https://doi.org/10.1016/j.jpha.2017.05.003).

Varshavi, Dorsa , Varshavi, Dorna, Everett, Jeremy (2016), The role of pharmacometabonomics in predicting drug pharmacokinetics. In: , , , . , International Journal of Pharmacokinetics, 1 (1) . pp. 5-8 ISSN: 2053-0846 (Print), 2053-0854 (Online) (doi: https://doi.org/10.4155/ipk-2016-0010).

Hooper, D. , Clarke, F.C., Mitchell, J.C., Snowden, M.J. (2016), A modern approach to the Heckel Equation: The effect of compaction pressure on the yield pressure of ibuprofen and its sodium salt. OMICS International. In: , , , . OMICS International, Journal of Nanomedicine and Nanotechnology, 7 (381) . pp. 2 2157-7439 (Online) (doi: http://dx.doi.org/10.4172/2157-7439.1000381).

Maniruzzaman, Mohammed , Farias, Smirna, Slipper, Ian J., Boateng, Joshua S. , Chowdhry, Babur Z. , Nair, Arun , Douroumis, Dennis (2016), Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing. Wiley. In: , , , . Wiley, Journal of Pharmacy and Pharmacology, 68 (7) . pp. 890-900 ISSN: 0022-3573 (Print), 2042-7158 (Online) (doi: http://doi.org/10.1111/jphp.12569) NB Item availability restricted.

Patent

Savage, Tammy , Wicks, Stephen, Mitchell, John (2019), Cyclodextrin. US Patent App. 10/239,961. In: , , , . US Patent App. 10/239,961, (doi: https://patents.google.com/patent/US10239961B2/en).