Undergraduate prospectus

Course Information

Intermediate Chemistry

Module summary

Module code: CHEM1038
Level: 5
Credits: 30
School: Engineering and Science
Department: Pharm, Chemical and Envi Science
Module Coordinator(s): Nichola Coleman

Specification

Aims

This course is designed to supplement material delivered in the Further Inorganic Chemistry, Further Organic Chemistry and Analytical Techniques courses. It aims to provide the opportunity to acquire knowledge of the occurrence, structure, reactivity and importance of selected natural products, to introduce the synthesis and uses of organometallic compounds, to introduce the concept of the symmetry of a molecule and to lay a foundation for its application for structure analysis and to develop a molecular orbital description for the bonding in inorganic and organic compounds.

Learning outcomes

On successful completion of this course a student will be able to:

Learning Outcome
1 Recognise the important types of compound which are classified as primary and secondary metabolites, and their interrelationship in metabolism.
2 Understand the important reactions and biosynthetic routes which lead to selected types of secondary metabolite and some of the practical techniques which are used to elucidate these routes.
3 Demonstrate a knowledge of the structures, occurrence, reactivities and importance of selected groups of natural products.
4 Appreciate the fundamental properties of metal-carbon bonds, their preparation, uses and industrial significance.
5 Demonstrate an understanding of the symmetry of a molecule and the application of symmetry character tables to vibrational spectroscopy and bonding.
6 Interpret infrared, mass, electronic and nmr spectra for structural elucidation of organic compounds.


1. Natural Products
A selection from:
Carbohydrates: classification, structures, reactions and functions
Amino acids, peptides and proteins: outline of structures, sequencing and synthetic methods.
Isoprenoids, steroids and carotenoids: classification, structures, reactions and biosynthesis.
Alkaloids; classification and structures, biosynthesis and structure determination.

2. Organometallic Chemistry
Organometallic compounds of Groups I, II, III and IV. Methods of preparation, structure and bonding. Applications in organic synthesis and industry. Organotransition metal compounds.

3. Symmetry
Elements and operations, molecular point groups, character tables, application to spectroscopy and bonding. Hückel molecular orbital method. Introduction to frontier molecular orbital theory.

4. Interpretive Spectroscopy
Application of infrared, electronic and NMR spectroscopy to structure elucidation.

Indicative content

1. Natural Products
A selection from:
Carbohydrates: classification, structures, reactions and functions
Amino acids, peptides and proteins: outline of structures, sequencing and synthetic methods.
Isoprenoids, steroids and carotenoids: classification, structures, reactions and biosynthesis.
Acetogenins: diversity, classification, structure determination and biosynthesis.
Nucleic acids: structures and functions.
Alkaloids; classification and structures, biosynthesis and structure determination.

2. Organometallic Chemistry
Organometallic compounds of Groups I, II, III and IV. Methods of preparation, structure and bonding. Applications in organic synthesis and industry. Organotransition metal compounds.

3. Symmetry
Elements and operations, molecular point groups, character tables, application to spectroscopy and bonding. Hückel molecular orbital method . Introduction to frontier molecular orbital theory.

4. Interpretive Spectroscopy
Application of infrared spectroscopy, mass spectra, electronic and nmr spectroscopy to structure elucidation.

Teaching and learning activity

The course will be taught largely through lectures and tutorials. The basic principles will be explained in the lectures, whilst the tutorials will establish the understanding of these principles by the study of their application in problem-solving exercises, in addition to consideration of student-centred problems. Associated laboratory classes will reinforce the activities of this course.

Assessment

Phase Tests 100% - 4 x phase tests all tests equally weighted.
Outcome 1-6
Pass mark - 40%