Pathophysiology of Disease

Module summary

Module code: ANAT1003
Level: 6
Credits: 15
School: Engineering and Science
Department: Science
Module Coordinator(s): Samer El-Daher



• To provide an in-depth approach to explaining mechanisms of human disease;
• To provide an overview of appropriate techniques used to evaluate selected disease processes;
• To develop a critical and analytical approach to explaining specific case histories of human disease.

Learning outcomes

On successful completion of this course a student will be able to:

Learning Outcome
1 discuss the mechanisms and changes associated with a range of diseases;
2 critically evaluate the use of clinical findings, imaging techniques, tests of physiological function and laboratory data in the identification, aetiology, diagnosis and pathogenesis of selected disease processes in human tissues and organs;
3 demonstrate a critical and analytical approach to specific case histories of human disease;
4 discuss the consequences of changes in morphology and physiology in selected disease states.

Indicative content

• Pathophysiology of enteric infections.
• Gastro-intestinal disease.
• Cardiovascular disease, atherosclerosis, myocardial infarction, conduction disorders.
• Acute and chronic pancreatitis.
• Correlation of cytopathology and histology.
• Haemotopathology.
• Hepatitis, cirrhosis and hepatomas.
• Respiratory disease; restrictive and obstructive disorders, asthma, pneumonia and respiratory distress syndrome. Cystic fibrosis.
• Neoplastic disease.
• Renal disease; classification and laboratory evaluation.
• Viral and bacterial meningitis.
• Parkinson's disease.
• Cerebrovascular accidents.
• Case study evaluations on a range of disorders, both guided and as self-study exercises.

Teaching and learning activity

The course will be delivered through keynote lectures, supported by tutorials / case study workshops. Lectures will explain underlying principles, which will be further explored during workshops. Workshops will involve discussions and problem-solving / analytical activities. Small-group work will develop students’ skills in interacting with others in a professional context, and will build on material delivered in lectures. Students will be strongly encouraged to use IT facilities to support their learning. Invited professional practitioners will contribute to presentations where appropriate, extending the knowledge base and experience of students. Practical demonstrations will also be used where appropriate.

Learning Time: (1 credit = 10 hours)

Scheduled contact hours:

Note: include in scheduled time: project supervision, demonstrations, practical classes and workshops, supervised time in studio or workshop, scheduled lab work , fieldwork, external visits, work-based learning where integrated into a structured academic programme:
lectures 16 8 x 2 hours
seminars 0
supervised practical sessions 0
tutorials 6 2 x 3 hours
formative assessment 6
other scheduled time 0
Guided independent study

Note: include in guided independent study preparation for scheduled sessions, follow up work, wider reading or practice, revision:
Independent coursework 16
Independent laboratory work 0
other non-scheduled time 106
Placements (including work placement and year abroad) 0
Total hours (’Should be equal to credit x 10’) 150


Coursework - 40%
1,250-1,500 words
Case history data will be supplied which students will be required to analyse and draw conclusions about mechanisms and progress of the disorder(s).
LO 1, 2, 3, 4.

Coursework - 60%
1,500-1,750 words
Scenario-based problem to assess students' ability to research & analyse information & presentation of conclusions in a clear & organised manner.
LO 1, 2, 3, 4.

Minimum pass mark - 40% overall.