Metabolism and Disease

Module summary

Module code: BIOC0581
Level: 5
Credits: 15
School: Engineering and Science
Department: Science
Module Coordinator(s): Lauren Pecorino

Specification

Aims

The aims of this module are: To provide an introduction to basic concepts in metabolism and the principles of metabolic pathways. To provide students with information on core metabolic pathways. To discuss relationships with metabolism and core disease pathways.

Learning outcomes

On successful completion of this module a student will be able to:
1. Discuss the details of the core metabolic pathways including regulation and integration.
2. Explain the basis of selected metabolic diseases.
3. Interpret a variety of types of experimental metabolic data, including some data you generate, identifying key characteristics of metabolic pathways.

Indicative content

Principles of metabolism and metabolic pathways, including regulation (e.g. hormonal) Inter-relationships between anabolism and catabolism
Metabolic significance of compartmentalisation in eukaryotic cells.
Bioenergetics: Thermodynamics of metabolism; equilibrium and non-equilibrium reactions
The role of ATP.
Enzyme kinetics; the role of co-factors and co-enzymes.
Specific metabolic pathways will be covered eg: Glycosis; Gluconeogenesis; glycogen metabolism; β-oxidation pathway; TCA cycle and associated anaplerotic pathways; Electron transport chain; Oxygen free radical metabolism; Amino acid metabolism;. In the context of metabolic processes, a range of diseases will be discussed, for example: kwashiorkor, gout, phenylketonuria, hyperammonemia, tyrosinaemia, glycogen storage disease (type V): McArdles syndrome.

Teaching and learning activity

The module will be delivered largely via lectures and practicals together with tutorials. Development of group working skills will also take place in practicals / tutorials.

Assessment

Practical: 40% weighting, 40% pass mark.
Learning outcome: 3.
Word Length: 1500 words.
Outline Details: A practical write up relevant to experimental and theoretical knowledge of the module.

Exam: 60% weighting, 40% pass mark.
Learning outcomes: 1, 2.
Outline Details: 1.5 hour exam.

Formative Assessment: Practical labs and tutorials.