Inflammation, Immune Disease and Allergy

Module summary

Module code: BIOL1052
Level: 7
Credits: 15
School: Engineering and Science
Department: Medway School of Pharmacy
Module Coordinator(s): Vadim Sumbayev / Bernhard Gibbs

Specification

Aims

The aim of this module is to give students a comprehensive understanding and knowledge of current problems and new insights into cell and molecular biology underlying inflammation, immune disease and allergy. The course will cover the impact of new research on our understanding of fundamental biological processes that relate to diseases such as cancer. The emphasis of this module is how basic science is translated into diagnostics and therapy; past, present and future.

Learning outcomes

On successful completion of this course a student will have:
an ability to professionally evaluate current research and advanced scholarship in key areas of cell and molecular biology underlying inflammation, immune disease and allergy

a comprehensive understanding of the concepts that underpin aspects of cancer, allergy, the function of the immune system and inflammation, and understand the development of novel/alternative therapeutics in these areas
a systematic understanding of new developments in the therapy of important disease states and evaluate how these methodologies may be translated into the clinical environment

an ability to critically appraise experimental strategies

the ability to plan and formulate accurate and concise communications to convey principles of scientific theories and ideas using a range of media

Indicative content

The indicative content will include:

Novel Cancer Therapy

Anticancer pro-drugs
Endogenous enzymes impacting carcinoma cell cycle and their activation
Chemical activation (hypoxia selective agents)
Antibody Directed Enzyme Pro-drug Therapy (ADEPT)


Allergic Inflammation

The differential control of IgE-mediated inflammatory and immunomodulatory mediator release from allergic effector cells
The problem of mast cell and basophil heterogeneity in developing and testing anti-allergic compounds
Inhibitory elements of the signal transduction cascade as innovative targets for developing new anti-allergic drugs
Novel mechanisms for the innate activation of allergic effector cells and their role in conditioning Th2-type immunity

Teaching and learning activity

The module comprises approximately 30 scheduled lecture hours and 30 tutorial and workshop hours. Total study hours are 150; the remaining 90 hours being made up of self-directed e-learning tasks (including forums) and self-directed learning.

Assessment

Critical Appraisal of recent key publication
Grading Mode Numeric
Weighting % 40%
Pass Mark 50%
Word Length 2000
LOs- 1,4,5


Written examination
Grading Mode- Numeric
Weighting % 60%
Pass Mark 50%
LOs- 2.3