Advanced and Clinical Immunology

Module summary

Module code: OBIO0049
Level: 6
Credits: 15
School: Engineering and Science
Department: Science
Module Coordinator(s): Giulia Getti / Martin Gonzo



The module will:
• provide a detailed review and understanding of the science of immunology and the conceptual and experimental framework underpinning modern immunology.
• provide an in-depth understanding of the physiology of the immune system and how it can go wrong in disease and the laboratory investigation of immune disorders.
• explain the role of the immune system during infection and both currently existing and experimental immunotherapeutic strategies for various disease states.
• integrate molecular, cellular, physiologic and pathologic aspects of the immune system.

Learning outcomes

On successful completion of this module a student will be able to:

1. Apply the detailed knowledge of the processes & principles of modern immunology obtained in the module to relate understanding of basic processes and principles by which the immune system works to how it may go wrong in disease states i.e. inappropriate immunological responses.
2. Discuss critically current understanding of the molecular and cellular basis of the immune system in health and disease as scientific reports or case studies interpretation.
3. Conduct appropriate literature-based research/evaluation of current research topic.
4. Understand and interpret aspects of both laboratory and experimentally derived data.

Indicative content

Overview of the immune system, cells and structural anatomy of the immune system, regulation of the immune response, structure and diversity generation of immunoglobulins and their clinical laboratory investigation, immunodeficiency, biochemistry and biology of complement, lymphocyte maturation and receptors and MHC molecules, cytokines and cytokine regulation of the immune response and inflammation, effector T-cells and inducible and natural regulatory T-cells Th1, Th2, Th17 etc, cytokine and anti-cytokine therapy, the role of adhesion molecules in immunity, immunology of transplantation and laboratory investigations, hypersensitivity, allergic disease and immunotherapy, laboratory investigation of allergy, immunological tolerance, autoimmunity and autoimmune disease, laboratory investigation of autoimmune diseases, current immunotherapy and experimental immunotherapy of immune disorders, immunology of infection i.e. selected viruses, bacteria and parasites, vaccines and vaccine development, novel and future vaccines.

Teaching and learning activity

The module will be taught through lectures and tutorial session for each topic three hours per week. Principles and understanding of the subject, including original data from primary research papers and other sources, in addition to current topics of research activity will be explained in lectures. Tutorials will be interactive and establish understanding of topic areas primarily through case studies and experimentally derived data. Appropriate online tutorial work will be used to provide background information and learning and guided independent study by students is also a requirement.


Group Presentation: 60% weighting, 40% pass mark.
Learning Outcomes: 1, 2, 3.
Word Length and Duration: 45 minutes + 250 word reflection.
Outline Details: Clinical case presentation.

Exam: 40% weighting, 40% pass mark.
Learning Outcomes: 2, 3, 4, 5.
Duration: 1 hour.
Outline Details: Seen Exam/Case study.

Formative Assessment: Students will be required to carry out peer marking in class. The principle of marking as well as correct answers will be discussed during lectures and used to provide feedback.