Key details
Professor Jeremy R Everett
Professor of Pharmaceutical Technologies
Professor Jeremy Everett is Professor of Pharmaceutical Technologies in the School of Science within the Faculty of Engineering and Science.
Professor Everett's main research focus is on metabolic profiling, also known as metabonomics or metabolomics. He has a particular interest in studying the consequences of genetic mutations on metabolic phenotypes and on the interplay between the genome and microbiome. He co-conceived, and co-named metabonomics together with Professor Jeremy Nicholson. He is a co-discoverer of pharmacometabonomics: which is the ability to predict the effects of drugs prior to dosing via metabolic profiling, and he is a co-inventor on a granted patent in this area. Professor Everett is a co-leader of the Medway Metabonomics Group (MMRG). He is also a Visiting Professor in the Department of Surgery and Cancer at Imperial College.
Professor Everett is the author of over 100 publications and reviews and a co-inventor on several patents.
Professor Everett consults for both major pharmaceutical and small biotech and research institutes on drug discovery. He is also a consultant for a New York law firm on pharmaceutical patents.
Prior to his current position, Professor Everett held a variety of drug discovery technology leadership positions at Pfizer, and before that GSK.
Professor Everett received both his BSc in chemistry and PhD in physical organic chemistry from Nottingham University. He was a Post-doctoral Fellow at McMaster University in Hamilton, Ontario, and a Research Associate at McGill University, Montréal.Recognition
- Fellow of the Royal Society of Chemistry (FRSC)
- Chartered Chemist (CChem)
- Visiting Professor, Faculty of Medicine, Imperial College, London
- Member of the American Chemical Society
- Member of the Metabolomics Society
- Member of Metabolite Identification Task Group
- Fellow of the Higher Education Academy
Research / Scholarly interests
Professor Jeremy Everett's research covers metabolic profiling i.e. metabonomics and pharmacometabonomics, with a particular focus on the relationship between genetic mutation and metabolic phenotype. His current work is focused on genotype – metabotype correlations in the areas of obesity and ageing and he is a co-inventor on a recently filed patent on an anti-obesogenic agent.
Recent publications
Article
Veeravalli, Sunil , Varshavi, Dorsa, Scott, Flora H, Varshavi, Dorna , Pullen, Francis , Veselkov, Kirill , Phillips, Ian R , Everett, Jeremy , Shephard, Elizabeth (2022), Treatment of wild-type mice with 2,3-butanediol, a urinary biomarker of Fmo5-/- mice, decreases plasma cholesterol and epididymal fat deposition. Frontiers Media SA. In: , , , . Frontiers Media SA, Frontiers in Physiology, 13: 859681 . pp. 1-13 1664-042X (Online) (doi: https://doi.org/10.3389/fphys.2022.859681).
Varshavi, Dorna , Varshavi, Dorsa, McCarthy, Nicola, Veselkov, Kirill , Keun, Hector C. , Everett, Jeremy R. (2021), Metabonomics study of the effects of single copy mutant KRAS in the presence or absence of WT allele using human HCT116 isogenic cell lines. Springer Nature. In: , , , . Springer Nature, Metabolomics, 17: 104 (12) ISSN: 1573-3882 (Print), 1573-3890 (Online) (doi: https://doi.org/10.1007/s11306-021-01852-w).
Varshavi, Dorna , Varshavi, Dorsa, Veselkov, Kirill, McCarthy, Nicola , Keun, Hector C. , Everett, Jeremy R. , Horizon Discovery (2020), Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines. Springer. In: , , , . Springer, Metabolomics, 16: 51 (4) ISSN: 1573-3882 (Print), 1573-3890 (Online) (doi: https://doi.org/10.1007/s11306-020-01674-2).
Veeravalli, Sunil , Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa , Everett, Jeremy R. , Shephard, Elizabeth A. (2020), Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. American Society for Pharmacology and Experimental Therapeutics (ASPET). In: , , , . American Society for Pharmacology and Experimental Therapeutics (ASPET), Drug Metabolism and Disposition, 48 (4) ISSN: 0090-9556 (Print), 1521-009X (Online) (doi: https://doi.org/10.1124/dmd.119.089995) NB Item availability restricted.
Everett, Jeremy R. , Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. , Nicholson, Jeremy K. (2019), A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Elsevier. In: , , , . Elsevier, Trends in Pharmacological Sciences, 40 (10) . pp. 763-773 ISSN: 0165-6147 (Print), 1873-3735 (Online) (doi: https://doi.org/10.1016/j.tips.2019.08.004).
Scott, Flora H. , Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R. , Veselkov, Kirill , Strittmatter, Nicole , Takats, Zoltan , Shephard, Elizabeth A. , Everett, Jeremy R. (2018), Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers Media. In: , , , . Frontiers Media, Frontiers in Molecular Biosciences, 5: 28 2296-889X (Online) (doi: https://doi.org/10.3389/fmolb.2018.00028).
Everett, Jeremy R. and , (2017), NMR-based pharmacometabonomics: A new paradigm for personalised or precision medicine. Elsevier. In: , , , . Elsevier, Progress in Nuclear Magnetic Resonance Spectroscopy, 102-3 . pp. 1-14 ISSN: 0079-6565 (Print), 1873-3301 (Online) (doi: https://doi.org/10.1016/j.pnmrs.2017.04.003).
Varshavi, Dorsa , Varshavi, Dorna, Everett, Jeremy (2016), The role of pharmacometabonomics in predicting drug pharmacokinetics. In: , , , . , International Journal of Pharmacokinetics, 1 (1) . pp. 5-8 ISSN: 2053-0846 (Print), 2053-0854 (Online) (doi: https://doi.org/10.4155/ipk-2016-0010).
Bell, Andrew S. , Bradley, Joseph, Everett, Jeremy, Loesel, Jens , McLoughlin, David , Mills, James , Peakman, Marie-Claire , Sharp, Robert E. , Williams, Christine , Zhu, Hongyao (2016), Plate-based diversity subset screening generation 2: An improved paradigm for high throughput screening of large compound files. Springer Verlag. In: , , , . Springer Verlag, Molecular Diversity, 20 (4) . pp. 789-803 ISSN: 1381-1991 (Print), 1573-501X (Online) (doi: http://dx.doi.org/10.1007/s11030-016-9692-9) NB Item availability restricted.
Everett, Jeremy R. and , (2016), From metabonomics to pharmacometabonomics: The role of metabolic profiling in personalized medicine. Frontiers Media S.A.. In: , , , . Frontiers Media S.A., Frontiers in Pharmacology, 7: 297 ISSN: 1663-9812 (Print), (doi: http://dx.doi.org/10.3389/fphar.2016.00297).
Sanchon-Lopez, Beatriz and , Everett, Jeremy (2016), New methodology for known metabolite identification in metabonomics / metabolomics: topological metabolite identification carbon efficiency (tMICE). American Chemical Society. In: , , , . American Chemical Society, Journal of Proteome Research, 15 (9) . pp. 3405-3419 ISSN: 1535-3893 (Print), 1535-3907 (Online) (doi: http://dx.doi.org/10.1021/acs.jproteome.6b00631).
Everett, Jeremy R. , Dona, Anthony C., Kyriakides, Michael, Scott, Flora , Shephard, Elizabeth A. , Varshavi, Dorsa , Veselkov, Kirill (2016), A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments. Elsevier. In: , , , . Elsevier, Computational and Structural Biotechnology Journal, 14 . pp. 135-153 ISSN: 2001-0370 (Print), 2001-0370 (Online) (doi: https://doi.org/10.1016/j.csbj.2016.02.005).
Book section
Everett, Jeremy and , (2019), Pharmacometabonomics: the prediction of drug effects using metabolic profiling. Springer. In: , , In: James E. Barrett, Clive P. Page, Martin C. Michel (eds.), Concepts and Principles of Pharmacology: 100 Years of the Handbook of Experimental Pharmacology. Springer, Cham, Switzerland , 260 (1st) . pp. 263-300 . ISBN: 9783030353612 (doi: https://doi.org/10.1007/164_2019_316).
Everett, Jeremy and , (2018), Applications of metabolic phenotyping in pharmaceutical research and development. Elsevier. In: , , In: John C. Lindon, Jeremy K. Nicholson, Elaine Holmes (eds.), The Handbook of Metabolic Phenotyping. Elsevier, . pp. 407-448 . ISBN: 9780128122938 (doi: https://www.elsevier.com/books/the-handbook-of-metabolic-phenotyping/lindon/978-0-12-812293-8) NB Item availability restricted.
Everett, Jeremy , Lindon, John, Nicholson, Jeremy (2016), Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. Elsevier Science Publishing Co Inc. In: , , In: Jeremy Nicholson, A Darzi, John Lindon, Elaine Holmes (eds.), Metabolic Phenotyping in Personalized and Public Healthcare. Elsevier Science Publishing Co Inc, . pp. 137-165 . ISBN: 9780128003442 (doi: https://doi.org/10.1016/B978-0-12-800344-2.00006-9) NB Item availability restricted.
Conference item
Said, Mohamed , Thompson, Elinor, Everett, Jeremy (2021), Modulation of ageing by genetic knock-out, phototherapy and drugs in the C. elegans worm. Biochemical Society - British Society for Research on Ageing (BSRA). In: Metabolism of Ageing, 06 - 08 Sep 2021, online In: Cathy Slack, James Brown (eds.), A JOINT BIOCHEMICAL SOCIETY & BSRA ONLINE CONFERENCE: Metabolism of Ageing 6-8 September 2021 ONLINE. Biochemical Society - British Society for Research on Ageing (BSRA), Aston University, UK / Trustee, British Society for Research on Ageing (doi: https://bsra.org.uk/bsra-biochemical-society-metabolism-of-ageing-meeting/) NB Item availability restricted.
Said, Mohamed , Thompson, Elinor, Everett, Jeremy (2019), Metabolic ageing in the C. elegans worm and modulation by genetic knock-out, phototherapy and drugs. The Genetics Society. In: UK C.elegans meeting, 16th September 2019, Imperial College London, Sir Alexander Fleming Building, Imperial College Rd, London, UK , UK C.elegans Meeting London 16 September 2019 Proceedings. The Genetics Society, (doi: http://p35-preview.runhosting.com/londonelegans2019.co.uk/) NB Item availability restricted.
Everett, Jeremy and , Sanchon Lopez, Beatriz (2016), New Approaches to NMR-Based Metabolite Identification. In: 12th Annual Conference of the Metabolomics Society, 27 June 2016 - 30 June 2016, Dublin, Eire , . , (doi: http://metabolomics2016.org/images/Metabolomic-Conference-detailed-programme-6-20-16.pdf).
Patent
Everett, Jeremy , Varshavi, Dorsa, Shephard, Elizabeth, Veeravalli, Sunil (2021), Patent - Treatment of obesity and related conditions. In: , , , . , (doi: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2021038253).