Professor Jeremy Everett

Professor Jeremy Everett BSc, PhD, FRSC, CChem

Professor of Pharmaceutical Technologies

Key details

Professor Jeremy R Everett

Professor of Pharmaceutical Technologies


Professor Jeremy Everett is Professor of Pharmaceutical Technologies in the School of Science within the Faculty of Engineering and Science.

Professor Everett's main research focus is on metabolic profiling, also known as metabonomics or metabolomics. He has a particular interest in studying the consequences of genetic mutations on metabolic phenotypes and on the interplay between the genome and microbiome. He co-conceived, and co-named metabonomics together with Professor Jeremy Nicholson. He is a co-discoverer of pharmacometabonomics: which is the ability to predict the effects of drugs prior to dosing via metabolic profiling, and he is a co-inventor on a granted patent in this area. Professor Everett is a co-leader of the Medway Metabonomics Group (MMRG). He is also a Visiting Professor in the Department of Surgery and Cancer at Imperial College.  

Professor Everett is the author of over 100 publications and reviews and a co-inventor on several patents.

Professor Everett consults for both major pharmaceutical and small biotech and research institutes on drug discovery. He is also a consultant for a New York law firm on pharmaceutical patents.

Prior to his current position, Professor Everett held a variety of drug discovery technology leadership positions at Pfizer, and before that GSK.

Professor Everett received both his BSc in chemistry and PhD in physical organic chemistry from Nottingham University. He was a Post-doctoral Fellow at McMaster University in Hamilton, Ontario, and a Research Associate at McGill University, Montréal.

Responsibilities within the university

 Deputy Course Leader BSc Pharmaceutical Science.

Recognition

  • Fellow of the Royal Society of Chemistry (FRSC)
  • Chartered Chemist (CChem)
  • Visiting Professor, Faculty of Medicine, Imperial College, London
  • Member of the American Chemical Society
  • Member of the Metabolomics Society
  • Member of Metabolite Identification Task Group
  • Fellow of the Higher Education Academy

Research / Scholarly interests

Professor Jeremy Everett's research covers metabolic profiling i.e. metabonomics and pharmacometabonomics, with a particular focus on the relationship between genetic mutation and metabolic phenotype. His current work is focused on genotype – metabotype correlations in the areas of obesity and ageing and he is a co-inventor on a recently filed patent on an anti-obesogenic agent.

Recent publications

Article

Varshavi, Dorna , Varshavi, Dorsa, Veselkov, Kirill, McCarthy, Nicola , Keun, Hector C. , Everett, Jeremy R. , Horizon Discovery (2020), Metabolic characterization of colorectal cancer cells harbouring different KRAS mutations in codon 12, 13, 61 and 146 using human SW48 isogenic cell lines. Springer. In: , , , . Springer, Metabolomics, 16: 51 (4) ISSN: 1573-3882 (Print), 1573-3890 (Online) (doi: https://doi.org/10.1007/s11306-020-01674-2).

Veeravalli, Sunil , Phillips, Ian R., Freire, Rafael T., Varshavi, Dorsa , Everett, Jeremy R. , Shephard, Elizabeth A. (2020), Flavin-Containing Monooxygenase 1 (FMO1) catalyzes the production of taurine from hypotaurine. American Society for Pharmacology and Experimental Therapeutics (ASPET). In: , , , . American Society for Pharmacology and Experimental Therapeutics (ASPET), Drug Metabolism and Disposition, 48 (4) ISSN: 0090-9556 (Print), 1521-009X (Online) (doi: https://doi.org/10.1124/dmd.119.089995) NB Item availability restricted.

Everett, Jeremy R. , Holmes, Elaine, Veselkov, Kirill A., Lindon, John C. , Nicholson, Jeremy K. (2019), A unified conceptual framework for metabolic phenotyping in diagnosis and prognosis. Elsevier. In: , , , . Elsevier, Trends in Pharmacological Sciences, 40 (10) . pp. 763-773 ISSN: 0165-6147 (Print), 1873-3735 (Online) (doi: https://doi.org/10.1016/j.tips.2019.08.004).

Scott, Flora H. , Varshavi, Dorsa, Veeravalli, Sunil, Phillips, Ian R. , Veselkov, Kirill , Strittmatter, Nicole , Takats, Zoltan , Shephard, Elizabeth A. , Everett, Jeremy R. (2018), Metabolic biomarkers of ageing in C57BL/6J wild-type and flavin-containing monooxygenase 5 (FMO5)-knockout mice. Frontiers Media. In: , , , . Frontiers Media, Frontiers in Molecular Biosciences, 5: 28 2296-889X (Online) (doi: https://doi.org/10.3389/fmolb.2018.00028).

Everett, Jeremy R. and , (2017), NMR-based pharmacometabonomics: A new paradigm for personalised or precision medicine. Elsevier. In: , , , . Elsevier, Progress in Nuclear Magnetic Resonance Spectroscopy, 102-3 . pp. 1-14 ISSN: 0079-6565 (Print), 1873-3301 (Online) (doi: https://doi.org/10.1016/j.pnmrs.2017.04.003).

Varshavi, Dorsa , Varshavi, Dorna, Everett, Jeremy (2016), The role of pharmacometabonomics in predicting drug pharmacokinetics. In: , , , . , International Journal of Pharmacokinetics, 1 (1) . pp. 5-8 ISSN: 2053-0846 (Print), 2053-0854 (Online) (doi: https://doi.org/10.4155/ipk-2016-0010).

Bell, Andrew S. , Bradley, Joseph, Everett, Jeremy, Loesel, Jens , McLoughlin, David , Mills, James , Peakman, Marie-Claire , Sharp, Robert E. , Williams, Christine , Zhu, Hongyao (2016), Plate-based diversity subset screening generation 2: An improved paradigm for high throughput screening of large compound files. Springer Verlag. In: , , , . Springer Verlag, Molecular Diversity, 20 (4) . pp. 789-803 ISSN: 1381-1991 (Print), 1573-501X (Online) (doi: http://dx.doi.org/10.1007/s11030-016-9692-9) NB Item availability restricted.

Everett, Jeremy R. and , (2016), From metabonomics to pharmacometabonomics: The role of metabolic profiling in personalized medicine. Frontiers Media S.A.. In: , , , . Frontiers Media S.A., Frontiers in Pharmacology, 7: 297 ISSN: 1663-9812 (Print), (doi: http://dx.doi.org/10.3389/fphar.2016.00297).

Sanchon-Lopez, Beatriz and , Everett, Jeremy (2016), New methodology for known metabolite identification in metabonomics / metabolomics: topological metabolite identification carbon efficiency (tMICE). American Chemical Society. In: , , , . American Chemical Society, Journal of Proteome Research, 15 (9) . pp. 3405-3419 ISSN: 1535-3893 (Print), 1535-3907 (Online) (doi: http://dx.doi.org/10.1021/acs.jproteome.6b00631).

Everett, Jeremy R. , Dona, Anthony C., Kyriakides, Michael, Scott, Flora , Shephard, Elizabeth A. , Varshavi, Dorsa , Veselkov, Kirill (2016), A guide to the identification of metabolites in NMR-based metabonomics/metabolomics experiments. Elsevier. In: , , , . Elsevier, Computational and Structural Biotechnology Journal, 14 . pp. 135-153 ISSN: 2001-0370 (Print), 2001-0370 (Online) (doi: https://doi.org/10.1016/j.csbj.2016.02.005).

Everett, Jeremy R. and , (2015), Academic drug discovery: Current status and prospects. Routledge Taylor & Francis. In: , , , . Routledge Taylor & Francis, Expert Opinion on Drug Discovery, 10 (9) . pp. 937-944 ISSN: 1746-0441 (Print), 1746-045X (Online) (doi: http://dx.doi.org//10.1517/17460441.2015.1059816).

Gonzalez Malagon, Sandra G. , Melidoni, Anna N., Hernandez, Diana, Omar, Bilal A. , Houseman, Lyndsey , Veeravalli, Sunil , Scott, Flora , Varshavi, Dorsa , Everett, Jeremy , Tsuchiya, Yugo (2015), The phenotype of a knockout mouse identifies flavin-containing monooxygenase 5 (FMO5) as a regulator of metabolic ageing. Elsevier Inc.. In: , , , . Elsevier Inc., Biochemical Pharmacology, 96 (3) . pp. 267-277 ISSN: 0006-2952 (Print), (doi: http://dx.doi.org/10.1016/j.bcp.2015.05.013) NB Item availability restricted.

Everett, Jeremy R. and , (2015), Pharmacometabonomics in humans: a new tool for personalized medicine. Future Medicine Ltd.. In: , , , . Future Medicine Ltd., Pharmacogenomics, 16 (7) . pp. 737-754 ISSN: 1462-2416 (Print), (doi: http://dx.doi.org/10.2217/PGS.15.20) NB Item availability restricted.

Everett, Jeremy R. and , (2015), A new paradigm for known metabolite identification in metabonomics/metabolomics: Metabolite identification efficiency. Elsevier B.V.. In: , , , . Elsevier B.V., Computational and Structural Biotechnology Journal, 13 . pp. 131-144 ISSN: 2001-0370 (Print), (doi: http://dx.doi.org/10.1016/j.csbj.2015.01.002) NB Item availability restricted.

Everett, Jeremy , Loo, Ruey Leng, Pullen, Francis S. (2013), Pharmacometabonomics and personalized medicine. Royal Society of Medicine Press. In: , , , . Royal Society of Medicine Press, Annals of Clinical Biochemistry, 50 (6) . pp. 523-545 ISSN: 0004-5632 (Print), 1758-1001 (Online) (doi: http://dx.doi.org/10.1177/0004563213497929) NB Item availability restricted.

Bell, Andrew S. , Bradley, Joseph, Everett, Jeremy R., Knight, Michelle , Loesel, Jens , Mathias, John , McLoughlin, David , Mills, James , Sharp, Robert E. , Williams, Christine (2013), Plate-based diversity subset screening: an efficient paradigm for high throughput screening of a large screening file. Springer Netherlands. In: , , , . Springer Netherlands, Molecular Diversity, 17 (2) . pp. 319-335 ISSN: 1381-1991 (Print), 1573-501X (Online) (doi: http://dx.doi.org/10.1007/s11030-013-9438-x).

Everett, Jeremy R. and , (2013), Report on the 10th Anniversary of International Drug Discovery Science and Technology Conference, 8-10 November 2012, Nanjing, China. Informa Plc. In: , , , . Informa Plc, Expert Opinion on Drug Discovery, 8 (3) . pp. 357-361 ISSN: 1746-0441 (Print), 1746-045X (Online) (doi: http://dx.doi.org/10.1517/17460441.2013.762353).

Book section

Everett, Jeremy and , (2019), Pharmacometabonomics: the prediction of drug effects using metabolic profiling. Springer. In: , , In: James E. Barrett, Clive P. Page, Martin C. Michel (eds.), Concepts and Principles of Pharmacology: 100 Years of the Handbook of Experimental Pharmacolog. Springer, Cham, Switzerland , 260 (1st) . pp. 263-300 . ISBN: 9783030353612 (doi: https://doi.org/10.1007/164_2019_316) NB Item availability restricted.

Everett, Jeremy and , (2018), Applications of metabolic phenotyping in pharmaceutical research and development. Elsevier. In: , , In: John C. Lindon, Jeremy K. Nicholson, Elaine Holmes (eds.), The Handbook of Metabolic Phenotypin. Elsevier, . pp. 407-448 . ISBN: 9780128122938 (doi: https://www.elsevier.com/books/the-handbook-of-metabolic-phenotyping/lindon/978-0-12-812293-8) NB Item availability restricted.

Everett, Jeremy , Lindon, John, Nicholson, Jeremy (2016), Pharmacometabonomics and predictive metabonomics: New tools for personalised medicine. Elsevier Science Publishing Co Inc. In: , , In: Jeremy Nicholson, A Darzi, John Lindon, Elaine Holmes (eds.), Metabolic Phenotyping in Personalized and Public Healthcar. Elsevier Science Publishing Co Inc, . pp. 137-165 . ISBN: 9780128003442 (doi: https://doi.org/10.1016/B978-0-12-800344-2.00006-9) NB Item availability restricted.

Everett, Jeremy and , (2015), NMR-based pharmacometabonomics: A new approach to personalised medicine. John Wiley & Sons Ltd. In: , , In: Jeremy Everett, Robin Harris, John Lindon, Ian Wilaon (eds.), NMR in Pharmaceutical Science. John Wiley & Sons Ltd, Chichester, UK , 4 . pp. 359-372 . ISBN: 9780470034590 (doi: http://dx.doi.org/ 10.1002/9780470034590.emrstm1395) NB Item availability restricted.

Everett, Jeremy R. and , (2015), Drug discovery and development: the role of NMR. John Wiley & Sons, Ltd.. In: , , , eMagRe. John Wiley & Sons, Ltd., London, UK eMagRes, 4 (1) . pp. 137-150 . ISBN: 9780470034590 (doi: http://dx.doi.org/10.1002/9780470034590.emrstm1389) NB Item availability restricted.

Conference item

Said, Mohamed , Thompson, Elinor, Everett, Jeremy (2019), Metabolic ageing in the C. elegans worm and modulation by genetic knock-out, phototherapy and drugs. The Genetics Society. In: UK C.elegans meeting, 16th September 2019, Imperial College London, Sir Alexander Fleming Building, Imperial College Rd, London, UK , UK C.elegans Meeting London 16 September 2019 Proceeding. The Genetics Society, (doi: http://p35-preview.runhosting.com/londonelegans2019.co.uk/) NB Item availability restricted.

Everett, Jeremy and , Sanchon Lopez, Beatriz (2016), New Approaches to NMR-Based Metabolite Identification. In: 12th Annual Conference of the Metabolomics Society, 27 June 2016 - 30 June 2016, Dublin, Eire , . , (doi: http://metabolomics2016.org/images/Metabolomic-Conference-detailed-programme-6-20-16.pdf).

Everett, Jeremy and , (2015), From metabonomics to pharmacometabonomics: Mice, men and microbiota. In: Neuviemes Journees Scientifiques du Reseau Francais de Metabolomique et Fluxomique, 9 -11 June 2015, Lille, France , . , (doi: ).

Everett, Jeremy and , (2015), Pharmacogenomics and pharmacometabonomics for personalised medicine. In: FOCUS 2015: National Meeting of the Association for Clinical Biochemistry & Laboratory Medicine, 8-11 June 2015, Cardiff, Wales , . , . pp. 3-3 (doi: http://www.focus-acb.org/2015/userfiles/file/Focus_2015_Handbook_v15_Layout_1.pdf).

Everett, Jeremy and , (2015), From metabonomics to pharmacometabonomics: An NMR-based excursion from metabolite profiling to precision medicine. In: Invited Lecture at Institute of Food Research, 19 March 2015, Institute of Food Research, Norwich, UK , . , (doi: ).

Everett, Jeremy and , (2015), From metabonomics to pharmacometabonomics: Mice, men and m microbiota. In: University College London Spring Seminars, 25 February 2015, University College London, UK , . , (doi: ).

Everett, Jeremy and , (2014), Pharmacometabonomics: An important new paradigm for precision medicine. In: Metabomeeting 2014, 10-12 Sep 2014, The Royal Institution, London, UK , . , (doi: ).

Everett, Jeremy and , (2014), Pharmacometabonomics: The ability to use pre-dose metabolite profiles to predict drug responses. In: EMBL Practical Course: Metabolomics Bioinformatics for Life Scientists, 17- 21 March, 2014, Hinxton Genome Campus, UK , . , (doi: ).

Everett, Jeremy and , (2013), New approaches to personalised medicine via pharmacometabonomics. In: Lifescience R&D Big Data Leaders Forum, 3-5 Dec 2013, Basel, Switzerland , . , (doi: ).

Everett, Jeremy and , (2013), New approaches to the design of large screening files for lead discovery. In: Lifescience R&D Big Data Leaders Forum, 3-5 Dec 2013, Basel, Switzerland , . , (doi: ).

Edited book

Everett, Jeremy , Harris, Robin, Lindon, John, Wilson, Ian (2015), NMR in pharmaceutical sciences. Wiley. In: , , , . Wiley, (1st ed.) . ISBN: 9781118997666 (doi: http://eu.wiley.com/WileyCDA/WileyTitle/productCd-1118660250.html).