Peter Griffiths

Professor Peter Griffiths BSc, PhD, DSc

Professor of Formulation

Professor Peter Griffiths' interest in nanotechnology, traditionally known as colloid science, started with a final year undergraduate research project on ferrofluids.  Thereafter followed a PhD (University of Bristol, 1991), focused on developing NMR and scattering methodology to quantify the dynamics of polymer-polymer and polymer-particle blends, that saw Professor Griffiths' interests broaden into concentrated particle dispersions, and then to polymer-surfactant and polymer-small molecule systems, with post-doctoral research periods at University of Bristol (1991-1993) and the Royal Institute of Technology, Stockholm (1993-1995).

In 1995, Professor Griffiths was appointed to a lectureship at Cardiff University that further consolidated these research themes, and took his attention towards the drug delivery field, in particular polymer-drug and polymer-protein conjugates, small molecule gels and vesicle dispersions.

Professor Griffiths’ contribution to the research field and education in general was recognized with the award of a DSc (University of Bristol, 2005), a "docenture" (Royal Institute of Technology, Stockholm, 2005) and conferment of Fellow of the Royal Society of Chemistry, FRSC in 2002. He has also received distinguished service awards from both the SCI and the RSC.

Responsibilities within the university

Whilst maintaining a research profile, Professor Griffiths' main role within the University is as Director of Greenwich Research and Enterprise (GRE) (https://enterprise.gre.ac.uk/).  This role focuses on supporting the wider academic community by providing centralised support and resource to grow the research and enterprise activity across the University.

Awards

Long service awards from RSC and SCI for extended work on technical interest and local member groups.

Research / Scholarly interests

Understanding, and ultimately controlling, the interactions of one group of molecules in a complex mixture is fundamental to many of the challenges we face over the next few decades, the associated need to be able to more efficiently assemble precisely controlled structures. Factors that determine these characteristic interactions are the subject of investigation in Griffiths' research, which utilizes, adapts and develops scattering and spectroscopic methodology to achieve its goals. To date, he has published just over 110 articles that have attracted over 2600 citations. His H-index is 31.

Professor Griffiths' current research activities are a healthy mix of "old and new"; the group continues to employ PGSE-NMR and SANS to examine polymer-polymer, polymer-surfactant and polymer-small molecule interactions.

More recently, Professor Griffiths has developed a significant interest in the design and preparation of multi-modal drug delivery systems, and as part of the Alexander FP7 consortium, the challenges associated with delivery of actives through mucosal layers.

A continuing interest is the elaboration of the fundamental structure-activity relationships of metallosurfactants, molecules that combine catalytic (chemical) activity with a physical (interfacial) activity. Newer projects are focusing on the role of polymers and particles in the stabilization of aqueous foams; paint dispersions containing mixtures of adsorbed and non-adsorbed polymers; sterically stabilised (formulated) systems challenged by competing surfaces or other surface active species, as well we the design and preparation of hierarchical structured particles. The research focuses on a mix of aqueous and non-aqueous systems.

As a consequence of this output, the experimental toolbox employed by Professor Griffiths has been expanded to include a range of various spin-resonance techniques (pulsed-gradient spin-echo, PGSE-NMR, electrophoretic NMR, eNMR and electron paramagnetic resonance, EPR, as well as neutron scattering in conjunction with other lab based methodologies, such as surface tension, fluorescence and rheology.

Recent publications

Article

Patel, Leesa , Mansour, Omar Tarek, Bryant, Hannah, Abdullahi, Wasiu , Dalgliesh, Robert M. , Griffiths, Peter C. (2020), On the interaction of low molecular weight poly(diallyldimethylammonium chloride) and sodium dodecylsulphate in low surfactant-polyelectrolyte ratio, salt-free solutions. American Chemical Society. In: , , , . American Chemical Society, Langmuir, 36 (30) . pp. 8815-8825 ISSN: 0743-7463 (Print), 1520-5827 (Online) (doi: https://doi.org/10.1021/acs.langmuir.0c01149) NB Item availability restricted.

Lazzari, Federica , Alexander, Bruce D., Dalgliesh, Robert M., Alongi, Jenny , Ranucci, Elisabetta , Ferruti, Paolo , Griffiths, Peter C. (2020), pH-Dependent Chiral Recognition of D- and L-Arginine Derived Polyamidoamino Acids by Self-assembled Sodium Deoxycholate. MDPI. In: , , , . MDPI, Polymers, 12: 900 (4) 2073-4360 (Online) (doi: https://doi.org/10.3390/polym12040900).

El-Betany, Alaa M.M. , Kamoun, Elbadawy A., James, Craig, Jangher, Abdulhakim , Aljayyoussi, Ghaith , Griffiths, Peter , McKeown, Neil B. , Gumbleton, Mark (2020), Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences. Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics, 579: 119187 ISSN: 0378-5173 (Print), 1873-3476 (Online) (doi: https://doi.org/10.1016/j.ijpharm.2020.119187) NB Item availability restricted.

Abdullahi, Wasiu , Crossman, Martin, Griffiths, Peter Charles (2020), Surfactant-modulation of the cationic-polymer-induced aggregation of anionic particulate dispersions. MDPI. In: , , , . MDPI, Polymers, 12: 287 (2) 2073-4360 (Online) (doi: https://dx.doi.org/10.3390/polym12020287).

Patel, Leesa , Mansour, Omar, Crossman, Martin, Griffiths, Peter (2019), Electrophoretic NMR characterisation of charged sidechain cationic polyelectrolytes and their interaction with the anionic surfactant, sodium dodecyl sulfate. American Chemical Society. In: , , , . American Chemical Society, Langmuir, 35 (28) . pp. 9233-9238 ISSN: 0743-7463 (Print), 1520-5827 (Online) (doi: https://doi.org/10.1021/acs.langmuir.9b01324).

Ibrahim, Mervat S. , King, Stephen, Murray, Martin, Szczygiel, Agnieszka , Alexander, Bruce D. , Griffiths, Peter C. (2019), Surfactant modulated interactions of hydrophobically modified ethoxylated urethane (HEUR) polymers with penetrable surfaces. Elsevier. In: , , , . Elsevier, Journal of Colloid and Interface Science, 552 . pp. 9-16 ISSN: 0021-9797 (Print), (doi: https://doi.org/10.1016/j.jcis.2019.05.035).

Mansour, Omar T. , Cattoz, Beatrice, Beaube, Manon, Heenan, Richard K. , Schweins, Ralf , Hurcom, Jamie , Griffiths, Peter C. (2019), Segregation versus interdigitation in highly dynamic polymer/surfactant layers. MDPI. In: , , , . MDPI, Polymers, 11: 109 (1) 2073-4360 (Online) (doi: https://doi.org/10.3390/polym11010109).

Shafik Ibrahim, Mervat , Rogers, Sarah, Mahmoudy, Najat, Murray, Martin , Szczygiel, Agnieszka , Green, Beth , Alexander, Bruce D. , Griffiths, Peter C. (2018), Surfactant modulated interaction of hydrophobically modified ethoxylated urethane (HEUR) polymers with impenetrable surfaces. Elsevier. In: , , , . Elsevier, Journal of Colloid and Interface Science, 539 . pp. 126-134 ISSN: 0021-9797 (Print), 1095-7103 (Online) (doi: https://doi.org/10.1016/j.jcis.2018.12.059).

Inchaurraga, Laura , Martínez-López, Ana L., Cattoz, Beatrice, Griffiths, Peter C. , Wilcox, Matthey , Pearson, Jeffrey P. , Quincoces, Gemma , Peñuelas, Iván , Martin-Arbella, Nekane , Irache, Juan M. (2018), The effect of thiamine-coating nanoparticles on their biodistribution and fate following oral administration. Elsevier. In: , , , . Elsevier, European Journal of Pharmaceutical Sciences, 128 . pp. 81-90 ISSN: 0928-0987 (Print), 1879-0720 (Online) (doi: https://doi.org/10.1016/j.ejps.2018.11.025).

Paul, Alison , Fallis, Ian A., Stokes, Emily C., King, Stephen M. , Griffiths, Peter (2018), Structural evolution in metallomicroemulsions – the effect of increasing alcohol hydrophobicity. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Dalton Transactions . pp. 1-7 ISSN: 1477-9226 (Print), 1477-9234 (Online) (doi: https://doi.org/10.1039/C8DT02031K).

Ibrahim, Mervat S. , Valencony, Jordane, King, Stephen, Murray, Martin , Szczygiel, Agnieszka , Alexander, Bruce D. , Griffiths, Peter C. (2018), Studying the interaction of hydrophobically modified ethoxylated urethane (HEUR) polymers with sodium dodecylsulphate (SDS) in concentrated polymer solutions. Elsevier. In: , , , . Elsevier, Journal of Colloid and Interface Science, 529 . pp. 588-598 ISSN: 0021-9797 (Print), (doi: https://doi.org/10.1016/j.jcis.2018.06.042) NB Item availability restricted.

Hossain, M.R. , Wray, D., Paul, A., Griffiths, P.C. (2017), Probing the surfaces of core-shell and hollow nanoparticles by solvent relaxation NMR. Wiley. In: , , , . Wiley, Magnetic Resonance in Chemistry, 56 (4) . pp. 251-256 ISSN: 0749-1581 (Print), 1097-458X (Online) (doi: https://doi.org/10.1002/mrc.4707).

Mansour, Omar T. , Cattoz, Beatrice, Beaube, Manon, Montagnon, Morganne , Heenan, Richard K. , Schweins, Ralf , Appavou, Marie-Sousai , Griffiths, Peter C. (2017), Assembly of small molecule surfactants at highly dynamic air-water interfaces. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Soft Matter ISSN: 1744-683X (Print), 1744-6848 (Online) (doi: https://doi.org/10.1039/C7SM01914A).

Powell, Alison , Caterson, Bruce, Hughes, Clare, Paul, Alison , James, Craig , Hopkins, Stephen , Mansour, Omar , Griffiths, Peter (2017), Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route?. Informa Healthcare. In: , , , . Informa Healthcare, Journal of Drug Targeting . pp. 1-22 ISSN: 1061-186X (Print), 1029-2330 (Online) (doi: https://doi.org/10.1080/1061186X.2017.1378660).

Morris, Christopher J. , Aljayyoussi, Ghaith, Mansour, Omar, Griffiths, Peter , Gumbleton, Mark (2017), Endocytic uptake, transport and macromolecular interactions of anionic PAMAM dendrimers within lung tissue. Springer US & AAPS (American Association of Pharmaceutical Scientists). In: , , , . Springer US & AAPS (American Association of Pharmaceutical Scientists), Pharmaceutical Research . pp. 1-15 ISSN: 0724-8741 (Print), 1573-904X (Online) (doi: https://doi.org/10.1007/s11095-017-2190-7).

Pritchard, Manon F. , Powell, Lydia C., Khan, Saira, Griffiths, Peter C. , Mansour, Omar T. , Schweins, Ralf , Beck, Konrad , Buurma, Niklaas J. , Dempsey, Christopher E. , Wright, Chris J. (2017), The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Nature Publishing Group. In: , , , . Nature Publishing Group, Scientific Reports, 7: 44731 ISSN: 2045-2322 (Print), 2045-2322 (Online) (doi: https://doi.org/10.1038/srep44731).

Mauro, Nicolò , Chiellini, Federica, Bartoli, Cristina, Gazzarri, Matteo , Laus, Michele , Antonioli, Diego , Griffiths, Peter , Manfredi, Amedea , Ranucci, Elisabetta , Ferruti, Paolo (2016), RGD-mimic polyamidoamine-montmorillonite composites with tunable stiffness as scaffolds for bone tissue-engineering applications. Wiley. In: , , , . Wiley, Journal of Tissue Engineering and Regenerative Medicine, 11 (7) . pp. 2164-2175 ISSN: 1932-6254 (Print), 1932-7005 (Online) (doi: http://dx.doi.org/10.1002/term.2115).

Cardoso, Andre Zamith , Mears, Laura L. E., Cattoz, Beatrice N., Griffiths, Peter C. , Schweins, Ralf , Adams, Dave J. (2016), Linking micellar structures to hydrogelation for salt-triggered dipeptide gelators. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Soft Matter, 12 (15) . pp. 3612-3621 ISSN: 1744-683X (Print), 1744-6848 (Online) (doi: https://doi.org/10.1039/C5SM03072B).

Roberts, Jessica L. , Cattoz, Beatrice N., Schweins, Ralf, Beck, Konrad , Thomas, David W. , Griffiths, Peter , Ferguson, Elaine L. (2016), In vitro evaluation of the interaction of dextrin-colistin conjugates with bacterial lipopolysaccharide.. American Chemical Society. In: , , , . American Chemical Society, Journal of Medicinal Chemistry ISSN: 0022-2623 (Print), 1520-4804 (Online) (doi: http://dx.doi.org/10.1021/acs.jmedchem.5b01521).

Et-Tarhouni, Zaineb O. , Carter, Emma, Murphy, Damien M., Griffiths, Peter , Mansour, Omar T. , King, Stephen M. , Paul, Alison (2015), Quantifying the micellar structure formed from hydrocarbon-fluorocarbon surfactants. Elsevier. In: , , , . Elsevier, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 492 . pp. 255-262 ISSN: 0927-7757 (Print), (doi: http://dx.doi.org/10.1016/j.colsurfa.2015.12.015).

Dyer, Paul D.R. , Shepherd, Thomas R., Gollings, Alexander S., Shorter, Susan A. , Gorringe-Pattrick, Monique A. M. , Tang, Chun-Kit , Cattoz, Beatrice N. , Baillie, Les , Griffiths, Peter C. , Richardson, Simon C.W. (2015), Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity. Elsevier B.V.. In: , , , . Elsevier B.V., Journal of Controlled Release, 220 (A) . pp. 316-328 ISSN: 0168-3659 (Print), (doi: http://dx.doi.org/10.1016/j.jconrel.2015.10.054) NB Item availability restricted.

Cosgrove, Terence , Swier, Steven, Schmidt, Randall G., Muangpil, Sairoong , Espidel, Youssef , Griffiths, Peter , Prescott, Stuart W. (2015), Impact of end-tethered polyhedral nanoparticles on the mobility of poly(dimethylsiloxane). American Chemical Society Publications. In: , , , . American Chemical Society Publications, Langmuir, 31 (30) . pp. 8469-8477 ISSN: 0743-7463 (Print), 1520-5827 (Online) (doi: http://dx.doi.org/10.1021/acs.langmuir.5b01211).

Griffiths, Peter Charles , Cattoz, Beatrice, Ibrahim, Mervat Shafik, Anuonye, Josephine Chibuzor (2015), Probing the interaction of nanoparticles with mucin for drug delivery applications using dynamic light scattering. Elsevier B.V.. In: , , , . Elsevier B.V., European Journal of Pharmaceutics and Biopharmaceutics, 97 (A) . pp. 218-222 ISSN: 0939-6411 (Print), (doi: http://dx.doi.org/10.1016/j.ejpb.2015.05.004).

Mansour, Omar T. , Cattoz, Beatrice N., Heenan, Richard K., King, Stephen M. , Griffiths, Peter (2015), Probing competitive interactions in quaternary formulations. Elsevier. In: , , , . Elsevier, Journal of Colloid and Interface Science, 454 . pp. 35-43 ISSN: 0021-9797 (Print), 1095-7103 (Online) (doi: http://dx.doi.org/10.1016/j.jcis.2015.04.068).

Pereira de Sousa, Irene , Cattoz, Beatrice, Wilcox, Matthew D., Griffiths, Peter C. , Dagliesh, Robert , Rogers, Sarah , Bernkop-Schnürch, Andreas (2015), Nanoparticles decorated with proteolytic enzymes, a promising strategy to overcome the mucus barrier. Elsevier B.V.. In: , , , . Elsevier B.V., European Journal of Pharmaceutics and Biopharmaceutics, 97 (A) . pp. 257-264 ISSN: 0939-6411 (Print), (doi: http://dx.doi.org/10.1016/j.ejpb.2015.01.008).

Abdulkarim, Muthanna , Agulló, Nuria, Cattoz, Beatrice, Griffiths, Peter , Bernkop-Schnürch, Andreas , Borros, Salvador Gómez , Gumbleton, Mark (2015), Nanoparticle diffusion within intestinal mucus: Three-dimensional response analysis dissecting the impact of particle surface charge, size and heterogeneity across polyelectrolyte, pegylated and viral particles. Elsevier B.V.. In: , , , . Elsevier B.V., European Journal of Pharmaceutics and Biopharmaceutics, 97 (A) . pp. 230-238 ISSN: 0939-6411 (Print), (doi: https://doi.org/10.1016/j.ejpb.2015.01.023).

Grießinger, Julia , Dünnhaupt, Sarah, Cattoz, Beatrice N., Griffiths, Peter , Oh, Sejin , Gómez, Salvador Borrós , Wilcox, Matthew , Pearson, Jeffrey , Gumbleton, Mark , Bernkop-Schnürch, Andreas (2015), Methods to determine the interactions of micro- and nanoparticles with mucus. Elsevier B.V.. In: , , , . Elsevier B.V., European Journal of Pharmaceutics and Biopharmaceutics, 96 . pp. 464-476 ISSN: 0939-6411 (Print), (doi: http://dx.doi.org/10.1016/j.ejpb.2015.01.005).

Raeburn, Jaclyn , Mendoza-Cuenca, Cristina, Cattoz, Beatrice N., Little, Marc A. , Terry, Ann E. , Zamith Cardoso, Andre , Griffiths, Peter C. , Adams, Dave J. (2014), The effect of solvent choice on the gelation and final hydrogel properties of Fmoc–diphenylalanine. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Soft Matter, 11 (5) . pp. 927-935 ISSN: 1744-683X (Print), 1744-6848 (Online) (doi: http://dx.doi.org/10.1039/C4SM02256D).

Samaridou, Eleni , Karidi, Konstantina, de Sousa, Irene Pereira, Cattoz, Beatrice , Griffiths, Peter , Kammona, Olga , Bernkop-Schnürch, Andreas , Kiparissides, Costas (2014), Enzyme-functionalized PLGA nanoparticles with enhanced mucus permeation rate. World Scientific Publishing Company. In: , , , . World Scientific Publishing Company, Nano LIFE, 4: 144101 (4) . pp. 1-11 ISSN: 1793-9844 (Print), 1793-9852 (Online) (doi: http://dx.doi.org/10.1142/S179398441441013X) NB Item availability restricted.

Colquhoun, Catherine , Draper, Emily R., Eden, Edward G. B., Cattoz, Beatrice N. , Morris, Kyle L. , Chen, Lin , McDonald, Tom O. , Terry, Ann E. , Griffiths, Peter C. , Serpell, Louise C. (2014), The effect of self-sorting and co-assembly on the mechanical properties of low molecular weight hydrogels. Royal Society of Chemistry Publishing. In: , , , . Royal Society of Chemistry Publishing, Nanoscale, 6 (22) . pp. 13719-13725 ISSN: 2040-3364 (Print), 2040-3372 (Online) (doi: http://dx.doi.org/10.1039/C4NR04039B) NB Item availability restricted.

Pettit, Marie , Dyer, Paul D.R., Mitchell, John C., Griffiths, Peter C. , Alexander, Bruce , Cattoz, Beatrice , Heenan, Richard K. , King, Stephen M. , Schweins, Ralf , Pullen, Frank (2014), Construction and physiochemical characterisation of a multi-composite, potential oral vaccine delivery system (VDS). Elsevier B.V.. In: , , , . Elsevier B.V., International Journal of Pharmaceutics, 468 (1-2) . pp. 264-271 ISSN: 0378-5173 (Print), (doi: http://dx.doi.org/10.1016/j.ijpharm.2014.03.046) NB Item availability restricted.

Hurcom, Jamie , Paul, Alison, Heenan, Richard K., Davies, Alun , Woodman, Nicholas , Schweins, Ralf , Griffiths, Peter C. (2014), The interfacial structure of polymeric surfactant stabilised air-in-water foams. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Soft Matter, 10 (17) . pp. 3003-3008 ISSN: 1744-683X (Print), 1744-6848 (Online) (doi: http://dx.doi.org/10.1039/c3sm52877d).

Casal-Dujat, Lucía , Griffiths, Peter C., Rodríguez-Abreu, Carlos, Solans, Conxita , Rogers, Sarah , Pérez-García, Lluïsa (2013), Nanocarriers from dicationic bis-imidazolium amphiphiles and their interaction with anionic drugs. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Journal of Materials Chemistry B, 1 (38) . pp. 4963-4971 ISSN: 2050-750X (Print), (doi: http://dx.doi.org/10.1039/C3TB20289E).

Cardoso, Andre Zamith , Alvarez Alvarez, Ana Estefania, Cattoz, Beatrice N., Griffiths, Peter C. , King, Stephen M. , Frith, William J. , Adams, Dave J. (2013), The influence of the kinetics of self-assembly on the properties of dipeptide hydrogels. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Faraday Discussions, 166 . pp. 101-116 ISSN: 1359-6640 (Print), 1364-5498 (Online) (doi: http://dx.doi.org/10.1039/C3FD00104K).

Griffiths, Peter C. , Mauro, Nicolo, Murphy, Damien M., Carter, Emma , Richardson, Simon C.W. , Dyer, Paul , Ferruti, Paolo (2013), Self-assembled PAA-based nanoparticles as potential gene and protein delivery systems. WILEY-VCH Verlag GmbH & Co. KGaA. In: , , , . WILEY-VCH Verlag GmbH & Co. KGaA, Macromolecular Bioscience, 13 (5) . pp. 641-649 ISSN: 1616-5187 (Print), 1616-5195 (Online) (doi: http://dx.doi.org/10.1002/mabi.201200462).

Morris, Kyle L. , Chen, Lin, Raeburn, Jaclyn, Sellick, Owen R. , Cotanda, Pepa , Paul, Alison , Griffiths, Peter C. , King, Stephen M. , O'Reilly, Rachel K. , Serpell, Louise C. (2013), Chemically programmed self-sorting of gelator networks. Nature Publishing Group. In: , , , . Nature Publishing Group, Nature Communications, 4: 1480 ISSN: 2041-1723 (Print), (doi: https://dx.doi.org/10.1038/ncomms2499).