Professor Peter Griffiths

Professor Peter Griffiths BSc, PhD, DSc

Professor of Formulation

Key details

Professor Peter C Griffiths
BSc, PhD, DSc

Professor of Formulation


Professor Peter Griffiths' interest in nanotechnology, traditionally known as colloid science, started with a final year undergraduate research project on ferrofluids.  Thereafter followed a PhD (University of Bristol, 1991), focused on developing NMR and scattering methodology to quantify the dynamics of polymer-polymer and polymer-particle blends, that saw Professor Griffiths' interests broaden into concentrated particle dispersions, and then to polymer-surfactant and polymer-small molecule systems, with post-doctoral research periods at University of Bristol (1991-1993) and the Royal Institute of Technology, Stockholm (1993-1995).

In 1995, Professor Griffiths was appointed to a lectureship at Cardiff University that further consolidated these research themes, and took his attention towards the drug delivery field, in particular polymer-drug and polymer-protein conjugates, small molecule gels and vesicle dispersions.

Professor Griffiths’ contribution to the research field and education in general was recognized with the award of a DSc (University of Bristol, 2005), a "docenture" (Royal Institute of Technology, Stockholm, 2005) and conferment of Fellow of the Royal Society of Chemistry, FRSC in 2002. He has also received distinguished service awards from both the SCI and the RSC.

Responsibilities within the university

Whilst maintaining a research profile, Professor Griffiths' main role within the University is as Director of Greenwich Research and Enterprise (GRE) (https://enterprise.gre.ac.uk/). This role focuses on supporting the wider academic community by developing and implementing the research and enterprise strategy and policies of the university addressing issues such as research capacity development, commercialisation and incentivisation, business engagement, and student enterprise, and the university's contribution to local economic development. To this end, Peter works with several groups to engender an enthusiastic research and knowledge exchange culture across the University, to drive the researcher training agenda of the university, and shaping university strategy and policies in this area.

Awards

Long service awards from RSC and SCI for extended work on technical interest and local member groups.

Recognition

Peter currently chairs a number of committees, including the SCI Rideal Trust and the ISIS Faculty Access Panel 8 (SANS), and is a member of the Editorial Board for the journal Polymers.

Research / Scholarly interests

Understanding, and ultimately controlling, the interactions of one group of molecules in a complex mixture is fundamental to many of the materials and sustainability challenges we face over the next few decades, driven by the associated need to be able to more efficiently assemble precisely controlled structures. Factors that determine these characteristic interactions are the subject of investigation in Griffiths' research, which utilizes, adapts and develops scattering and spectroscopic methodology to achieve its goals.

Professor Griffiths' current research activities deploy advanced spectroscopic and scattering methodologies to define structure-property relationships in complex formulations, typically those focusing on particle/polymer/surfactant/small molecule interactions. Often the molecules of interest have a biological or chemical activity, as well as a physical (interfacial) one. Recent projects focus on the role of polymers and particles in the stabilization of aqueous foams; paint dispersions containing mixtures of adsorbed and non-adsorbed polymers; sterically stabilised (formulated) systems challenged by competing surfaces or other surface active species, as well as the design and preparation of hierarchical structured particles. The research encompasses both a mix of aqueous and non-aqueous systems.

As a consequence of this activity, the experimental toolbox employed by Professor Griffiths has been expanded to include a range of various spin-resonance techniques (pulsed-gradient spin-echo, PGSE-NMR, electrophoretic NMR, eNMR and electron paramagnetic resonance, EPR, as well as neutron and X-ray scattering in conjunction with other lab based methodologies, such as surface tension, fluorescence and rheology.

Recent publications

Article

Patel, Leesa , Mansour, Omar Tarek, Bryant, Hannah, Abdullahi, Wasiu , Dalgliesh, Robert M. , Griffiths, Peter C. (2020), On the interaction of low molecular weight poly(diallyldimethylammonium chloride) and sodium dodecylsulphate in low surfactant-polyelectrolyte ratio, salt-free solutions. American Chemical Society. In: , , , . American Chemical Society, Langmuir, 36 (30) . pp. 8815-8825 ISSN: 0743-7463 (Print), 1520-5827 (Online) (doi: https://doi.org/10.1021/acs.langmuir.0c01149) NB Item availability restricted.

Lazzari, Federica , Alexander, Bruce D., Dalgliesh, Robert M., Alongi, Jenny , Ranucci, Elisabetta , Ferruti, Paolo , Griffiths, Peter C. (2020), pH-Dependent Chiral Recognition of D- and L-Arginine Derived Polyamidoamino Acids by Self-assembled Sodium Deoxycholate. MDPI. In: , , , . MDPI, Polymers, 12: 900 (4) 2073-4360 (Online) (doi: https://doi.org/10.3390/polym12040900).

El-Betany, Alaa M.M. , Kamoun, Elbadawy A., James, Craig, Jangher, Abdulhakim , Aljayyoussi, Ghaith , Griffiths, Peter , McKeown, Neil B. , Gumbleton, Mark (2020), Auto-fluorescent PAMAM-based dendritic molecules and their potential application in pharmaceutical sciences. Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics, 579: 119187 ISSN: 0378-5173 (Print), 1873-3476 (Online) (doi: https://doi.org/10.1016/j.ijpharm.2020.119187) NB Item availability restricted.

Abdullahi, Wasiu , Crossman, Martin, Griffiths, Peter Charles (2020), Surfactant-modulation of the cationic-polymer-induced aggregation of anionic particulate dispersions. MDPI. In: , , , . MDPI, Polymers, 12: 287 (2) 2073-4360 (Online) (doi: https://dx.doi.org/10.3390/polym12020287).

Patel, Leesa , Mansour, Omar, Crossman, Martin, Griffiths, Peter (2019), Electrophoretic NMR characterisation of charged sidechain cationic polyelectrolytes and their interaction with the anionic surfactant, sodium dodecyl sulfate. American Chemical Society. In: , , , . American Chemical Society, Langmuir, 35 (28) . pp. 9233-9238 ISSN: 0743-7463 (Print), 1520-5827 (Online) (doi: https://doi.org/10.1021/acs.langmuir.9b01324).

Ibrahim, Mervat S. , King, Stephen, Murray, Martin, Szczygiel, Agnieszka , Alexander, Bruce D. , Griffiths, Peter C. (2019), Surfactant modulated interactions of hydrophobically modified ethoxylated urethane (HEUR) polymers with penetrable surfaces. Elsevier. In: , , , . Elsevier, Journal of Colloid and Interface Science, 552 . pp. 9-16 ISSN: 0021-9797 (Print), (doi: https://doi.org/10.1016/j.jcis.2019.05.035).

Mansour, Omar T. , Cattoz, Beatrice, Beaube, Manon, Heenan, Richard K. , Schweins, Ralf , Hurcom, Jamie , Griffiths, Peter C. (2019), Segregation versus interdigitation in highly dynamic polymer/surfactant layers. MDPI. In: , , , . MDPI, Polymers, 11: 109 (1) 2073-4360 (Online) (doi: https://doi.org/10.3390/polym11010109).

Shafik Ibrahim, Mervat , Rogers, Sarah, Mahmoudy, Najat, Murray, Martin , Szczygiel, Agnieszka , Green, Beth , Alexander, Bruce D. , Griffiths, Peter C. (2018), Surfactant modulated interaction of hydrophobically modified ethoxylated urethane (HEUR) polymers with impenetrable surfaces. Elsevier. In: , , , . Elsevier, Journal of Colloid and Interface Science, 539 . pp. 126-134 ISSN: 0021-9797 (Print), 1095-7103 (Online) (doi: https://doi.org/10.1016/j.jcis.2018.12.059).

Inchaurraga, Laura , Martínez-López, Ana L., Cattoz, Beatrice, Griffiths, Peter C. , Wilcox, Matthey , Pearson, Jeffrey P. , Quincoces, Gemma , Peñuelas, Iván , Martin-Arbella, Nekane , Irache, Juan M. (2018), The effect of thiamine-coating nanoparticles on their biodistribution and fate following oral administration. Elsevier. In: , , , . Elsevier, European Journal of Pharmaceutical Sciences, 128 . pp. 81-90 ISSN: 0928-0987 (Print), 1879-0720 (Online) (doi: https://doi.org/10.1016/j.ejps.2018.11.025).

Paul, Alison , Fallis, Ian A., Stokes, Emily C., King, Stephen M. , Griffiths, Peter (2018), Structural evolution in metallomicroemulsions – the effect of increasing alcohol hydrophobicity. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Dalton Transactions . pp. 1-7 ISSN: 1477-9226 (Print), 1477-9234 (Online) (doi: https://doi.org/10.1039/C8DT02031K).

Ibrahim, Mervat S. , Valencony, Jordane, King, Stephen, Murray, Martin , Szczygiel, Agnieszka , Alexander, Bruce D. , Griffiths, Peter C. (2018), Studying the interaction of hydrophobically modified ethoxylated urethane (HEUR) polymers with sodium dodecylsulphate (SDS) in concentrated polymer solutions. Elsevier. In: , , , . Elsevier, Journal of Colloid and Interface Science, 529 . pp. 588-598 ISSN: 0021-9797 (Print), (doi: https://doi.org/10.1016/j.jcis.2018.06.042) NB Item availability restricted.

Hossain, M.R. , Wray, D., Paul, A., Griffiths, P.C. (2017), Probing the surfaces of core-shell and hollow nanoparticles by solvent relaxation NMR. Wiley. In: , , , . Wiley, Magnetic Resonance in Chemistry, 56 (4) . pp. 251-256 ISSN: 0749-1581 (Print), 1097-458X (Online) (doi: https://doi.org/10.1002/mrc.4707).

Mansour, Omar T. , Cattoz, Beatrice, Beaube, Manon, Montagnon, Morganne , Heenan, Richard K. , Schweins, Ralf , Appavou, Marie-Sousai , Griffiths, Peter C. (2017), Assembly of small molecule surfactants at highly dynamic air-water interfaces. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Soft Matter ISSN: 1744-683X (Print), 1744-6848 (Online) (doi: https://doi.org/10.1039/C7SM01914A).

Powell, Alison , Caterson, Bruce, Hughes, Clare, Paul, Alison , James, Craig , Hopkins, Stephen , Mansour, Omar , Griffiths, Peter (2017), Do model polymer therapeutics sufficiently diffuse through articular cartilage to be a viable therapeutic route?. Informa Healthcare. In: , , , . Informa Healthcare, Journal of Drug Targeting . pp. 1-22 ISSN: 1061-186X (Print), 1029-2330 (Online) (doi: https://doi.org/10.1080/1061186X.2017.1378660).

Morris, Christopher J. , Aljayyoussi, Ghaith, Mansour, Omar, Griffiths, Peter , Gumbleton, Mark (2017), Endocytic uptake, transport and macromolecular interactions of anionic PAMAM dendrimers within lung tissue. Springer US & AAPS (American Association of Pharmaceutical Scientists). In: , , , . Springer US & AAPS (American Association of Pharmaceutical Scientists), Pharmaceutical Research . pp. 1-15 ISSN: 0724-8741 (Print), 1573-904X (Online) (doi: https://doi.org/10.1007/s11095-017-2190-7).

Pritchard, Manon F. , Powell, Lydia C., Khan, Saira, Griffiths, Peter C. , Mansour, Omar T. , Schweins, Ralf , Beck, Konrad , Buurma, Niklaas J. , Dempsey, Christopher E. , Wright, Chris J. (2017), The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption. Nature Publishing Group. In: , , , . Nature Publishing Group, Scientific Reports, 7: 44731 ISSN: 2045-2322 (Print), 2045-2322 (Online) (doi: https://doi.org/10.1038/srep44731).

Mauro, Nicolò , Chiellini, Federica, Bartoli, Cristina, Gazzarri, Matteo , Laus, Michele , Antonioli, Diego , Griffiths, Peter , Manfredi, Amedea , Ranucci, Elisabetta , Ferruti, Paolo (2016), RGD-mimic polyamidoamine-montmorillonite composites with tunable stiffness as scaffolds for bone tissue-engineering applications. Wiley. In: , , , . Wiley, Journal of Tissue Engineering and Regenerative Medicine, 11 (7) . pp. 2164-2175 ISSN: 1932-6254 (Print), 1932-7005 (Online) (doi: http://dx.doi.org/10.1002/term.2115).

Cardoso, Andre Zamith , Mears, Laura L. E., Cattoz, Beatrice N., Griffiths, Peter C. , Schweins, Ralf , Adams, Dave J. (2016), Linking micellar structures to hydrogelation for salt-triggered dipeptide gelators. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, Soft Matter, 12 (15) . pp. 3612-3621 ISSN: 1744-683X (Print), 1744-6848 (Online) (doi: https://doi.org/10.1039/C5SM03072B).

Roberts, Jessica L. , Cattoz, Beatrice N., Schweins, Ralf, Beck, Konrad , Thomas, David W. , Griffiths, Peter , Ferguson, Elaine L. (2016), In vitro evaluation of the interaction of dextrin-colistin conjugates with bacterial lipopolysaccharide.. American Chemical Society. In: , , , . American Chemical Society, Journal of Medicinal Chemistry ISSN: 0022-2623 (Print), 1520-4804 (Online) (doi: http://dx.doi.org/10.1021/acs.jmedchem.5b01521).

Et-Tarhouni, Zaineb O. , Carter, Emma, Murphy, Damien M., Griffiths, Peter , Mansour, Omar T. , King, Stephen M. , Paul, Alison (2015), Quantifying the micellar structure formed from hydrocarbon-fluorocarbon surfactants. Elsevier. In: , , , . Elsevier, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 492 . pp. 255-262 ISSN: 0927-7757 (Print), (doi: http://dx.doi.org/10.1016/j.colsurfa.2015.12.015).

Dyer, Paul D.R. , Shepherd, Thomas R., Gollings, Alexander S., Shorter, Susan A. , Gorringe-Pattrick, Monique A. M. , Tang, Chun-Kit , Cattoz, Beatrice N. , Baillie, Les , Griffiths, Peter C. , Richardson, Simon C.W. (2015), Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity. Elsevier B.V.. In: , , , . Elsevier B.V., Journal of Controlled Release, 220 (A) . pp. 316-328 ISSN: 0168-3659 (Print), (doi: http://dx.doi.org/10.1016/j.jconrel.2015.10.054) NB Item availability restricted.

Cosgrove, Terence , Swier, Steven, Schmidt, Randall G., Muangpil, Sairoong , Espidel, Youssef , Griffiths, Peter , Prescott, Stuart W. (2015), Impact of end-tethered polyhedral nanoparticles on the mobility of poly(dimethylsiloxane). American Chemical Society Publications. In: , , , . American Chemical Society Publications, Langmuir, 31 (30) . pp. 8469-8477 ISSN: 0743-7463 (Print), 1520-5827 (Online) (doi: http://dx.doi.org/10.1021/acs.langmuir.5b01211).

Griffiths, Peter Charles , Cattoz, Beatrice, Ibrahim, Mervat Shafik, Anuonye, Josephine Chibuzor (2015), Probing the interaction of nanoparticles with mucin for drug delivery applications using dynamic light scattering. Elsevier B.V.. In: , , , . Elsevier B.V., European Journal of Pharmaceutics and Biopharmaceutics, 97 (A) . pp. 218-222 ISSN: 0939-6411 (Print), (doi: http://dx.doi.org/10.1016/j.ejpb.2015.05.004).

Mansour, Omar T. , Cattoz, Beatrice N., Heenan, Richard K., King, Stephen M. , Griffiths, Peter (2015), Probing competitive interactions in quaternary formulations. Elsevier. In: , , , . Elsevier, Journal of Colloid and Interface Science, 454 . pp. 35-43 ISSN: 0021-9797 (Print), 1095-7103 (Online) (doi: http://dx.doi.org/10.1016/j.jcis.2015.04.068).

Pereira de Sousa, Irene , Cattoz, Beatrice, Wilcox, Matthew D., Griffiths, Peter C. , Dagliesh, Robert , Rogers, Sarah , Bernkop-Schnürch, Andreas (2015), Nanoparticles decorated with proteolytic enzymes, a promising strategy to overcome the mucus barrier. Elsevier B.V.. In: , , , . Elsevier B.V., European Journal of Pharmaceutics and Biopharmaceutics, 97 (A) . pp. 257-264 ISSN: 0939-6411 (Print), (doi: http://dx.doi.org/10.1016/j.ejpb.2015.01.008).