Dr Solomon Habtemariam

Dr Solomon Habtemariam BSc, PGDip, MSc, PhD, MS, FRSM

Principal Lecturer, Pharmaceutical Sciences

Key details

Dr Solomon Habtemariam

Principal Lecturer, Pharmaceutical Sciences


Dr Solomon Habtemariam is a leading expert on drug discovery researches from natural sources. By using ethno-botanical information and bioassay-guided isolation studies, Dr Habtemariam's research has identified several classes of bioactive compounds. His in-house bioassay screens and expertise areas include:

  • Targeting inflammatory cytokines and adhesion molecules by natural products
  • Search for anti-microbial agents: antileishmanial, antibacterial and antifungal agents
  • Identification of potential anti-cancer and immunomodulatory compounds
  • Search for anticachexic agents from natural sources
  • Modulation of reactive oxygen species in health and disease.
  • Neurodegenerative diseases: principally Alzheimer's and Parkinson's diseases
  • Identification of antidiabetic agents from plant sources
  • Search of potential natural products that promote weight loss.

Hand-in-hand with the above-mentioned pharmacological assays, Dr Habtemariam uses chromatographic and spectroscopic analysis methods for standardising herbal products, i.e. he provides the scientific bases of traditional medicines through both chemical and pharmacological assays.

Recent publications

Article

Shirooie, Samira , Nabavi, Seyed Fazel, Dehpour, Ahmad R., Belwal, Tarun , Habtemariam, Solomon , Argüelles, Sandro , Sureda, Antoni , Daglia, Maria , Tomczyk, Michał , Sobarzo-Sanchez, Eduardo (2018), Targeting mTORs by omega-3 fatty acids: A possible novel therapeutic strategy for neurodegeneration?. Elsevier. In: , , , . Elsevier, Pharmacological Research, 135 . pp. 37-48 ISSN: 1043-6618 (Print), 1096-1186 (Online) (doi: https://doi.org/10.1016/j.phrs.2018.07.004).

Habtemariam, Solomon and , (2018), The brain-derived neurotrophic factor in neuronal plasticity and neuroregeneration: new pharmacological concepts for old and new drugs. Medknow Publications. In: , , , . Medknow Publications, Neural Regeneration Research, 13 (6) . pp. 983-984 ISSN: 1673-5374 (Print), 1876-7958 (Online) (doi: https://doi.org/10.4103/1673-5374.233438).

Caputo, Leonardo , Quintieri, Laura, Cavalluzzi, Maria Maddalena, Lentini, Giovanni , Habtemariam, Solomon (2018), Antimicrobial and antibiofilm activities of citrus water-extracts obtained by microwave-assisted and conventional methods. MDPI. In: , , , . MDPI, Biomedicines, 6: 70 (2) 2227-9059 (Online) (doi: https://doi.org/10.3390/biomedicines6020070).

Habtemariam, Solomon and , Lentini, Giovanni (2018), Plant-derived anticancer agents: Lessons from the pharmacology of geniposide and its aglycone, genipin. MDPI. In: , , , . MDPI, Biomedicines, 6: 39 (2) 2227-9059 (Online) (doi: https://doi.org/10.3390/biomedicines6020039).

Mbatchou, Valentine Chi , Dickson, Rita Akosua, Amponsah, Isaac Kingsley, Mensah, Abraham Yeboah , Habtemariam, Solomon (2018), Protection effect of the anthraquinones, cassiatorin and aurantio-obtusin from seeds of Senna tora against cowpea weevil attack. Elsevier B.V.. In: , , , . Elsevier B.V., Asian Pacific Journal of Tropical Biomedicine ISSN: 2221-1691 (Print), 2588-9222 (Online) (doi: https://doi.org/10.4103/2221-1691.225620).

Habtemariam, Solomon and , (2018), Molecular pharmacology of rosmarinic and salvianolic acids: Potential seeds for Alzheimer’s and vascular dementia drugs.. MDPI. In: , , , . MDPI, International Journal of Molecular Sciences, 19: 458 (2) . pp. 458 ISSN: 1661-6596 (Print), 1422-0067 (Online) (doi: https://doi.org/10.3390/ijms19020458).

Habtemariam, Solomon and , (2018), Iridoids and other Mmnoterpenes in the Alzheimer’s Brain: Recent development and future prospects. MDPI. In: , , , . MDPI, Molecules, 23: 117 (1) ISSN: 1420-3049 (Print), (doi: https://doi.org/10.3390/molecules23010117).

Habtemariam, Solomon and , (2017), Could we really use aloe vera food supplements to treat diabetes? Quality control issues. Hindawi Publishing Corporation. In: , , , . Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine ISSN: 1741-427X (Print), 1741-4288 (Online) (doi: https://doi.org/10.1155/2017/4856412).

Belwal, Tarun , Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad, Habtemariam, Solomon (2017), Dietary anthocyanins and insulin resistance: When food becomes a medicine. MDPI. In: , , , . MDPI, Nutrients, 9: 1111 (10) ISSN: 2072-6643 (Print), (doi: https://doi.org/10.3390/nu9101111).

Habtemariam, Solomon and , (2017), Methodology for rapid isolation of Moringin: Potential anticancer compound from the seeds of Moringa stenopetala. OMICS International. In: , , , . OMICS International, Pharmaceutica Analytica Acta, 8: 1000558 (8) 2153-2435 (Online) (doi: https://doi.org/10.4172/2153-2435.1000558).

Elufioye, Taiwo Olayemi , Berida, Tomayo Ireti, Habtemariam, Solomon (2017), Plants-derived neuroprotective agents: Cutting the cycle of cell death through multiple mechanisms. Hindawi Publishing Corporation. In: , , , . Hindawi Publishing Corporation, Evidence-Based Complementary and Alternative Medicine, 2017: 3574012 . pp. 1-27 ISSN: 1741-427X (Print), 1741-4288 (Online) (doi: https://doi.org/10.1155/2017/3574012).

Degennaro, Leonardo , Zenzola, Marina, Laurino, Annunziatina, Cavalluzzi, Maria Maddalena , Franchini, Carlo , Habtemariam, Solomon , Matucci, Rosanna , Luisi, Renzo , Lentini, Giovanni (2017), 2-Arylazetidines as ligands for nicotinic acetylcholine receptors. Springer US. In: , , , . Springer US, Chemistry of Heterocyclic Compounds, 53 (3) . pp. 329-334 ISSN: 0009-3122 (Print), 1573-8353 (Online) (doi: https://doi.org/10.1007/s10593-017-2061-5).

Gualdani, Roberta , Cavalluzzi, Maria, Lentini, Giovanni, Habtemariam, Solomon (2016), The chemistry and pharmacology of citrus limonoids. MDPI. In: , , , . MDPI, Molecules, 21: 1530 (11) . pp. 1-39 ISSN: 1420-3049 (Print), 1420-3049 (Online) (doi: https://doi.org/10.3390/molecules21111530).

Roselli, Mariagrazia , Cavalluzzi, Maria Maddalena, Bruno, Claudio, Lovece, Angelo , Carocci, Alessia , Franchini, Carlo , Habtemariam, Solomon , Lentini, Giovanni (2016), Synthesis and evaluation of berberine derivatives and analogues as potential anti-acetylcholinesterase and antioxidant agents. Elsevier. In: , , , . Elsevier, Phytochemistry Letters, 18 . pp. 150-156 ISSN: 1874-3900 (Print), 1876-7486 (Online) (doi: https://doi.org/10.1016/j.phytol.2016.10.005).

Habtemariam, Solomon and , (2016), Berberine and inflammatory bowel disease: A concise review. Elsevier. In: , , , . Elsevier, Pharmacological Research, 113 (Part A) . pp. 592-599 ISSN: 1043-6618 (Print), 1096-1186 (Online) (doi: https://doi.org/10.1016/j.phrs.2016.09.041).

Nabavi, Seyed Fazel , Maggi, Filippo, Daglia, Maria, Habtemariam, Solomon , Rastrelli, Luca , Nabavi, Seyed Mohammad (2016), Review: Pharmacological effects of Capparis spinosa L.. John Wiley & Sons, Ltd.. In: , , , . John Wiley & Sons, Ltd., Phytotherapy Research, 30 (11) . pp. 1733-1744 ISSN: 0951-418X (Print), 1099-1573 (Online) (doi: https://doi.org/10.1002/ptr.5684).

Roselli, Mariagrazia , Carocci, Alessia, Budriesi, Roberta, Micucci, Matteo , Toma, Maddalena , Di Cesare Mannelli, Lorenzo , Lovece, Angelo , Catalano, Alessia , Cavalluzzi, Maria Maddalena , Bruno, Claudio (2016), Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues. Elsevier Masson SAS. In: , , , . Elsevier Masson SAS, European Journal of Medicinal Chemistry, 121 . pp. 300-307 ISSN: 0223-5234 (Print), (doi: https://doi.org/10.1016/j.ejmech.2016.05.046).

Nabavi, Seyed Fazel , Habtemariam, Solomon, Di Lorenzo, Arianna, Sureda, Antoni , Khanjani, Sedigheh , Nabavi, Seyed Mohammad , Daglia, Maria (2016), Post-stroke depression modulation and in vivo antioxidant activity of gallic acid and its synthetic derivatives in a murine model system. MDPI. In: , , , . MDPI, Nutrients, 8 (5) . pp. 248 2072-6643 (Online) (doi: https://doi.org/10.3390/nu8050248).

Tsala, David Emery , Lannang, Alain Meli, Dimo, Theophile, Habtemariam, Solomon , Ekanga, Jean Arnaud , Guemmogne, Blandine Mbougen , Sewald, Norbert (2016), Antidiabetic and wound healing effects of smeathxanthone A. HATASO. In: , , , . HATASO, Recent Advances in Biology and Medicine, 2 . pp. 5-10 ISSN: 2378-654X (Print), (doi: https://doi.org/10.18639/RABM.2016.02.271146).

Habtemariam, Solomon and , (2016), The African Moringa is to change the lives of millions in Ethiopia and far beyond. Elsevier B.V.. In: , , , . Elsevier B.V., Asian Pacific Journal of Tropical Biomedicine, 6 (4) . pp. 355-356 ISSN: 2221-1691 (Print), (doi: https://doi.org/10.1016/j.apjtb.2015.12.016).

Habtemariam, Solomon and , (2016), Rutin as a natural therapy for Alzheimer’s disease: Insights into its mechanisms of action. Bentham Science Publishers. In: , , , . Bentham Science Publishers, Current Medicinal Chemistry, 23 (9) . pp. 860-873 ISSN: 0929-8673 (Print), (doi: https://doi.org/10.2174/0929867323666160217124333).

Nabavi, Seyed Fazel , Braidy, Nady, Habtemariam, Solomon, Sureda, Antoni , Manayi, Azadeh , Nabavi, Seyed Mohammad (2016), Neuroprotective effects of fisetin in Alzheimer’s and Parkinson's Diseases: From chemistry to medicine. Bentham Science Publishers. In: , , , . Bentham Science Publishers, Current Topics in Medicinal Chemistry, 16 (17) . pp. 1910-1915 ISSN: 1568-0266 (Print), 1873-4294 (Online) (doi: https://doi.org/10.2174/1568026616666160204121725).

Manikandan, Ramar , Thiagarajan, Raman, Goutham, Ganesh, Arumugam, Munusamy , Beulaja, Manikandan , Rastrelli, Luca , Skalicka-Woźniak, Krystyna , Habtemariam, Solomon , Orhan, Ilkay Erdogan , Nabavi, Seyed Fazel (2015), Zeaxanthin and ocular health, from bench to bedside. Elsevier. In: , , , . Elsevier, Fitoterapia, 109 . pp. 58-66 ISSN: 1873-6971 (Print), (doi: https://doi.org/10.1016/j.fitote.2015.12.009).

Roberto de Oliveira, Marcos , Nabavi, Seyed Fazel, Habtemariam, Solomon, Erdogan Orhan, Ilkay , Daglia, Maria , Nabavi, Seyed Mohammad (2015), The effects of baicalein and baicalin on mitochondrial function and dynamics: A review. Elsevier Ltd.. In: , , , . Elsevier Ltd., Pharmacological Research, 100 . pp. 296-308 ISSN: 1043-6618 (Print), (doi: http://dx.doi.org/10.1016/j.phrs.2015.08.021).

Civenni, G. , Iodice, M. G., Nabavi, S. F., Habtemariam, S. , Nabavi, S. M. , Catapano, C. V. , Daglia, M. (2015), Gallic acid and methyl-3-O-methyl gallate: a comparative study on their effects on prostate cancer stem cells. Royal Society of Chemistry. In: , , , . Royal Society of Chemistry, RSC Advances, 5 (78) . pp. 63800-63806 2046-2069 (Online) (doi: https://dx.doi.org/10.1039/C5RA07988H).

Shah, Muhammad Raza , Ishtiaq, , Hizbullah, Syed Muhammad, Habtemariam, Solomon , Zarrelli, Armando , Muhammad, Akhtar , Collina, Simona , Khan, Inamullah (2015), Protein tyrosine phosphatase 1B inhibitors isolated from Artemisia roxburghiana. Tayler and Francis. In: , , , . Tayler and Francis, Journal of Enzyme Inhibition and Medicinal Chemistty, 31 (4) . pp. 563-567 ISSN: 1475-6366 (Print), 1475-6374 (Online) (doi: https://doi.org/10.3109/14756366.2015.1047358).

Armah, Francis A. , Annan, Kofi, Mensah, Abraham Y., Amponsah, Isaac K. , Tocher, Derek A. , Habtemariam, Solomon (2015), Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.). Elsevier B.V.. In: , , , . Elsevier B.V., Fitoterapia, 105 . pp. 37-42 ISSN: 0367-326X (Print), (doi: http://dx.doi.org/10.1016/j.fitote.2015.06.001).

Manaye, Azadeh , Abdollahi, Mohammad, Thiagarajan, Raman, Nabavi, Seyed Fazel , Habtemariam, Solomon , Daglia, Maria , Nabavi, Seyed Mohammad (2015), Lutein and Cataract: from bench to bedside. Taylor & Francis. In: , , , . Taylor & Francis, Critical Reviews in Biotechnology, 36 (5) . pp. 829-839 ISSN: 0738-8551 (Print), 1549-7801 (Online) (doi: https://doi.org/10.3109/07388551.2015.1049510).

Álvarez, Ángel L. , Habtemariam, Solomon, Moneim, Ahmed, Melón, Santiago , Dalton, Kevin , Parra, Francisco (2015), A spiroketal-enol ether derivative from Tanacetum vulgare selectively inhibits HSV-1 and HSV-2 glycoprotein accumulation in Vero cells. Elsevier. In: , , , . Elsevier, Antiviral Research, 119 . pp. 8-18 ISSN: 0166-3542 (Print), 1872-9096 (Online) (doi: http://dx.doi.org/10.1016/j.antiviral.2015.04.004) NB Item availability restricted.

Lentini, Giovanni and , Habtemariam, Solomon (2015), Plotting intersections. Nature Publishing Group. In: , , , . Nature Publishing Group, Nature Methods (Correspondence), 12 (281) ISSN: 1548-7091 (Print), 1548-7105 (Online) (doi: http://dc.doi.org/10.1038/nmeth.3328).

Habtemariam, Solomon and , (2015), Investigation into the antioxidant and antidiabetic potential of Moringa stenopetala: Identification of the active principles. Natural Product Communications. In: , , , . Natural Product Communications, Natural Product Communications, 10 (3) . pp. 475-478 ISSN: 1934-578X (Print), 1555-9475 (Online) (doi: ).

Habtemariam, Solomon and , Lentini, Giovanni (2015), The therapeutic potential of rutin for diabetes: an update. Bentham Science Publishers B.V.. In: , , , . Bentham Science Publishers B.V., Mini-Reviews in Medicinal Chemistry, 15 (7) . pp. 524-528 ISSN: 1389-5575 (Print), 1875-5607 (Online) (doi: http://dx.doi.org/10.2174/138955751507150424103721).

Nabavi, Seyed Fazel , Sureda, Antoni, Habtemariam, Solomon, Nabavi, Seyed Mohammad (2015), Ginsenoside Rd and ischemic stroke; a short review of literatures. Elsevier B.V.. In: , , , . Elsevier B.V., Journal of Ginseng Research, 39 (4) . pp. 299-303 ISSN: 1226-8453 (Print), (doi: http://dx.doi.org/10.1016/j.jgr.2015.02.002).

Álvarez, Ángel L. , Habtemariam, Solomon, Parra, Francisco (2015), Inhibitory effects of lupene-derived pentacyclic triterpenoids from Bursera simaruba on HSV-1 and HSV-2 in vitro replication. Taylor & Francis. In: , , , . Taylor & Francis, Natural Product Research, 29 (24) . pp. 2322-2327 ISSN: 1478-6419 (Print), 1478-6427 (Online) (doi: http://dx.doi.org/10.1080/14786419.2015.1007456).

Lentini, Giovanni and , Habtemariam, Solomon (2015), Ebola therapy: Developing new drugs or repurposing old ones?. Elsevier Ireland Ltd.. In: , , , . Elsevier Ireland Ltd., International Journal of Cardiology, 179 . pp. 325 ISSN: 0167-5273 (Print), (doi: http://dx.doi.org/10.1016/j.ijcard.2014.11.092).

Habtemariam, Solomon and , Lentini, Giovanni (2015), Did Ebola survivors use plant medicines, and if so, which ones?. John Wiley & Sons. In: , , , . John Wiley & Sons, Phytotherapy Research, 29 (4) . pp. 632-632 ISSN: 0951-418X (Print), 1099-1573 (Online) (doi: http://dx.doi.org/10.1002/ptr.5279).

Habtemariam, Solomon and , Varghese, G.K. (2015), A Novel Diterpene Skeleton: Identification of a highly aromatic, cytotoxic and antioxidant 5-methyl-10-demethyl-abietane-type diterpene from Premna serratifolia.. John Wiley & Sons. In: , , , . John Wiley & Sons, Phytotherapy Research, 29 (1) . pp. 80-85 ISSN: 0951-418X (Print), 1099-1573 (Online) (doi: http://dx.doi.org/10.1002/ptr.5229).

Jackson, N. , Annan, K., Mensah, A.Y., Ekuadzi, E , Mensah, M.L.K. , Habtemariam, Solomon (2015), A novel triterpene from the roots of Paullinia pinnata: 6a-(3’-methoxy-4’-hydroxybenzoyl)-lup-20(29)-ene-3-one.. Natural Product Communications Inc.. In: , , , . Natural Product Communications Inc., Natural Product Communications, 10 (4) . pp. 563-564 ISSN: 1934-578X (Print), 1555-9475 (Online) (doi: http://www.naturalproduct.us/).

Nabavi, S. F. , Habtemariam, Solomon, Daglia, M., Shafighi, N. , Barber, A. J. , Nabavi, S.M. (2015), Anthocyanins as a potential therapy for diabetic retinopathy. Bentham Science Publishers. In: , , , . Bentham Science Publishers, Current Medicinal Chemistry, 22 (1) . pp. 51-58 ISSN: 0929-8673 (Print), 1875-533X (Online) (doi: http:dx.doi.org/10.2174/0929867321666140815123852#sthash.Fo34pIn9.dpuf).

Nabavi, S.M. , Habtemariam, Solomon, Daglia, M, Nabavi, S.F. (2015), Apigenin and Breast Cancers: from Chemistry to Medicine. Bentham Science Publishers. In: , , , . Bentham Science Publishers, Anticancer Agents in Medicinal Chemistry, 15 (6) . pp. 728 -735 ISSN: 1871-5206 (Print), (doi: http:dx.doi.org/10.2174/1871520615666150304120643#sthash.9UczvT47.dpuf).

Mireku, Evelyn A. , Mensah, Abraham Y., Mensah, Merlin L. K., Tocher, Derek A. , Habtemariam, Solomon (2014), Antiinflammatory properties of the stem-bark of anopyxis klaineana and its major constituent, methyl angolensate. John Wiley & Sons - Society for Psychotherapy Research - Routledge. In: , , , . John Wiley & Sons - Society for Psychotherapy Research - Routledge, Phytotherapy Research, 28 (12) . pp. 1855-1860 ISSN: 0951-418X (Print), 1099-1573 (Online) (doi: https://doi.org/10.1002/ptr.5212).

Curti, V. , Capelli, E., Nabavi, S. F., Habtemariam, Solomon , Nabavi, S. M. , Daglia, M. (2014), Modulation of human miR-17-3p expression by methyl 3-O-methyl gallate as explanation of its in vivo protective activities.. Wiley-VCH Verlag GmbH. In: , , , . Wiley-VCH Verlag GmbH, Molecular Nutrition & Food Research, 58 (9) . pp. 1776-1784 ISSN: 1613-4125 (Print), 1613-4133 (Online) (doi: http://dx.doi.org/10.1002/mnfr.201400007).

Tsala, David Emery , Habtemariam, Solomon, Simplice, Foyet Harquin, Ndzana, Martin Thierry Bella , Jital, Abraham Abraham , Dimo, Theophile (2014), Topically applied Tetrapleura tetraptera stem bark extract promotes healing of excision and incision wounds in rats. SAGEYA. In: , , , . SAGEYA, Journal of Intercultural Ethnopharmacology, 3 (2) . pp. 63-67 ISSN: 2146-8397 (Print), (doi: http://dx.doi.org/10.5455/jice.20140129034637).

Varghese, George K. , Diana, K. J., Habtemariam, Solomon (2014), In vitro studies on indigenous medicine for urolithiasis: Efficacy of aqueous extract of Aerva lanata (Linn.) Juss. Ex Schult on growth inhibition of calcium hydrogen phosphate dihydrate.. The Pharma Innovation. In: , , , . The Pharma Innovation, The Pharma Innovation International Journal, 3 (1) . pp. 92-100 ISSN: 2349-8242 (Print), 2277-7695 (Online) (doi: http://www.thepharmajournal.com/vol3Issue1/Issue_mar_2014/15.1.pdf).

Lentini, Giovanni and , Habtemariam, Solomon (2014), Microchip capillary electrophoresis–electrospray ionization mass spectrometry analysis of paracetamol metabolites in human urine: An intriguing case.. Elsevier. In: , , , . Elsevier, Journal of Chromatography A, 1327 . pp. 160 ISSN: 0021-9673 (Print), (doi: http://dx.doi.org/10.1016/j.chroma.2013.12.068).

Nabavi, Seyed Fazel , Daglia, Maria, Habtemariam, Solomon, Nabavi, Seyed Mohammad , Moghaddam, Akbar Hajizadeh (2014), Curcumin and liver health: From chemistry to medicine. Wiley. In: , , , . Wiley, Comprehensive Reviews in Food Science and Food Safety, 12 (1) . pp. 62-67 ISSN: 1541-4337 (Print), 1541-4337 (Online) (doi: http:dx.doi.org/10.1111/1541-4337.12047).

Habtemariam, Solomon and , Varghese, George K. (2014), The antidiabetic therapeutic potential of dietary polyphenols. Bentham Science Publishers. In: , , , . Bentham Science Publishers, Current Pharmaceutical Biotechnology, 15 (4) . pp. 391-400 ISSN: 1389-2010 (Print), 1873-4316 (Online) (doi: http://dx.doi.org/10.2174/1389201015666140617104643).

Book

Habtemariam, Solomon and , (2017), The African and Arabian Moringa Species: Chemistry, Bioactivity and Therapeutic Applications. Elsevier. In: , , , . Elsevier, Oxford/Amsterdam (1st) . ISBN: 9780081022863 (doi: https://www.elsevier.com/books/the-african-and-arabian-moringa-species/habtemariam/978-0-08-102286-3).