John Mitchell

Professor John Mitchell BA, MSc, PhD

Emeritus Professor of Biological Chemistry

Key details

Professor John Mitchell

Emeritus Professor of Biological Chemistry


Professor John Mitchell is an internationally recognised expert in pre-formulation and formulation science. He has published over 200 refereed papers in aspects of drug delivery, synthesis and analysis of novel drug carrying polymers, drug transport, drug formulation and the chemical stability of drug substances using spectroscopy and calorimetry as major tools.

Professor Mitchell has significant citation impact with an h index of 31 with over 3350 citations and an i10-index of 86. Please see: http://scholar.google.com/citations?hl=en&user=Dljt-_YAAAAJ.

Professor Mitchell has excellent industry links having had over 25 collaborative post-doctoral fellows with Pfizer UK and PhD students supported by GSK, Colorcon and Pfizer. The interdisciplinary nature of his work, based in both physical organic chemistry and pharmaceutical chemistry, is best expressed in a range of publications in journals ranging from Thermochimica Acta to International Journal of Pharmaceutics and interdisciplinary invited lectures including: 'Pharmaceutical Nanomaterials: The preparation of solid core drug delivery systems'.

Current and previous posts

  • 2010-Present: Emeritus Professor, University of Greenwich
  • 1999-2010: Professor of Biological Chemistry, University of Greenwich
  • 1991-1999: Senior Lecturer in Bio-organic Chemistry, University of Kent
  • 1987-1991: Senior Lecturer, University of Greenwich
  • 1983-1987: Teaching Fellow, University of London.

Qualifications

  • 1983: PhD, Physical Organic Chemistry, Duke University, USA
  • 1979: MSc, Organic Chemistry, Southern Illinois University, USA
  • 1977: BA Chemistry, Southern Illinois University, USA.

Responsibilities within the university

  • Emeritus Professor, Pharmaceutical Sciences Cluster Leader

Recognition

Professional activities

  • Appointed External Examiner to the University of the West Indies
  • Refereed papers for the American Chemical Society, Royal Society of Chemistry
  • Grants referee for EPSRC
  • Fellow Academy of Pharmaceutical Sciences.

Research / Scholarly interests

Professor Mitchell has attracted funding from both Research Councils (EPSRC) and industry (Pfizer, GlaxoSmithKline, and many SMEs) and has been an advisory consultant to GlaxoSmithKline, Procter and Gamble, Pfizer UK, Colorcon and Henkel AG & Co.

Professor Mitchell managed the Medway Sciences-Pfizer Postdoctoral Scheme, an innovative post-doctoral scheme involving a total of 24 post-doctoral research fellows, who were employed by the university but located within the Pfizer research and development laboratories at Sandwich.

Recent publications

Article

Ajiboye, Adejumoke Lara , Trivedi, Vivek, Mitchell, John (2020), Mesoporous silica particles as potential carriers for protein drug delivery: protein immobilisation and the effect of displacer on γ-globulin release. Taylor & Francis. In: , , , . Taylor & Francis, Drug Development and Industrial Pharmacy, Drug Development and Industrial Pharmacy, 46 (4) . pp. 576-586 ISSN: 0363-9045 (Print), 1520-5762 (Online) (doi: https://doi.org/10.1080/03639045.2020.1742141).

Trivedi, Vivek , Bhomia, Ruchir, Mitchell, John (2019), Myristic acid coated protein immobilised mesoporous silica particles as pH induced oral delivery system for the delivery of biomolecules. MDPI. In: , , , . MDPI, Pharmaceuticals, 12: 153 (4) ISSN: 1424-8247 (Print), (doi: https://dx.doi.org/10.3390/ph12040153).

Tighsazzadeh, Mohammad , Mitchell, John, Boateng, Joshua (2019), Development and evaluation of performance characteristics of timolol-loaded composite ocular films as potential delivery platform for treatment of glaucoma. Elsevier B.V.. In: , , , . Elsevier B.V., International Journal of Pharmaceutics, 566 . pp. 111-125 ISSN: 0378-5173 (Print), (doi: https://doi.org/10.1016/j.ijpharm.2019.05.059).

Shokry, Dina S. , Waters, Laura J., Parkes, Gareth M.B., Mitchell, John C. (2019), Prediction of human intestinal absorption using micellar liquid chromatography with an aminopropyl stationary phase. Wiley. In: , , , . Wiley, Biomedical Chromatography, 33: e4515 (7) ISSN: 0269-3879 (Print), 1099-0801 (Online) (doi: https://doi.org/10.1002/bmc.4515).

Shokry, Dina S. , Waters, Laura J., Parkes, Gareth M.B., Mitchell, John C. , Snowden, Martin J. (2018), Formation of a bile salt-drug hydrogel to predict human intestinal absorption. Elsevier. In: , , , . Elsevier, Journal of Pharmaceutical Sciences, 108 (1) . pp. 279-287 ISSN: 0022-3549 (Print), 1520-6017 (Online) (doi: https://doi.org/10.1016/j.xphs.2018.10.005).

Shokry, Dina S. , Waters, Laura J., Parkes, Gareth M. B., Mitchell, John C. (2018), Incorporating physiologically relevant mobile phases in micellar liquid chromatography for the prediction of human intestinal absorption. Wiley. In: , , , . Wiley, Biomedical Chromatography, 32: e4351 (12) ISSN: 0269-3879 (Print), 1099-0801 (Online) (doi: https://doi.org/10.1002/bmc.4351).

Majcen, Natasa , Mohsen, Reham, Snowden, Martin J., Mitchell, John C. , Voncina, Bojana (2018), The development of a novel smart material based on colloidal microgels and cotton. Elsevier. In: , , , . Elsevier, Advances in Colloid and Interface Science, 256 . pp. 193-202 ISSN: 0001-8686 (Print), 1095-7103 (Online) (doi: https://doi.org/10.1016/j.cis.2018.04.005).

Hooper, D. , Clarke, F. C., Docherty, R., Mitchell, J. C. , Snowden, M. J. (2017), Effects of crystal habit on the sticking propensity of ibuprofen — A case study. Elsevier B.V.. In: , , , . Elsevier B.V., International Journal of Pharmaceutics, 531 (1) . pp. 266-275 ISSN: 0378-5173 (Print), (doi: https://doi.org/10.1016/j.ijpharm.2017.08.091).

Ajiboye, Adejumoke Lara , Trivedi, Vivek, Mitchell, John C. (2017), Preparation of polycaprolactone nanoparticles via supercritical carbon dioxide extraction of emulsions. Springer US. In: , , , . Springer US, Drug Delivery and Translational Research . pp. 1-7 ISSN: 2190-393X (Print), 2190-3948 (Online) (doi: https://doi.org/10.1007/s13346-017-0422-3).

Waters, Laura J. , Finch, Catherine V., Bhuiyan, A.K.M. Mehedi H., Hemming, Karl , Mitchell, John C. (2017), Effect of plasma surface treatment of poly (dimethylsiloxane) on the permeation of pharmaceutical compounds. Elsevier. In: , , , . Elsevier, Journal of Pharmaceutical Analysis, 7 (5) . pp. 338-342 ISSN: 2095-1779 (Print), (doi: https://doi.org/10.1016/j.jpha.2017.05.003).

Waters, Laura J. , Shokry, Dina S., Parkes, Gareth M. B., Mitchell, John C. (2016), The use of bile salt micelles for the prediction of human intestinal absorption. Elsevier Inc.. In: , , , . Elsevier Inc., Journal of Pharmaceutical Sciences, 105 (12) . pp. 3611-3614 ISSN: 0022-3549 (Print), 1520-6017 (Online) (doi: http://dx.doi.org/10.1016/j.xphs.2016.09.007).

Khan, Sajjad , Trivedi, Vivek, Mitchell, John, Boateng, Joshua S. (2016), Conversion of sustained release omeprazole loaded buccal films into fast dissolving strips using supercritical carbon dioxide (scCO2) processing, for potential paediatric drug delivery. Elsevier B.V.. In: , , , . Elsevier B.V., European Journal of Pharmaceutical Sciences, 93 . pp. 45-55 ISSN: 0928-0987 (Print), (doi: http://dx.doi.org/10.1016/j.ejps.2016.08.007).

Hooper, D. , Clarke, F.C., Mitchell, J.C., Snowden, M.J. (2016), A modern approach to the Heckel Equation: The effect of compaction pressure on the yield pressure of ibuprofen and its sodium salt. OMICS International. In: , , , . OMICS International, Journal of Nanomedicine and Nanotechnology, 7 (381) . pp. 2 2157-7439 (Online) (doi: http://dx.doi.org/10.4172/2157-7439.1000381).

Mohsen, R. , Alexander, B. D., Richardson, S. C. W., Mitchell, J. C. , Diab, A. A. , Snowden, M. J. (2016), Design, synthesis, characterization and toxicity studies of Poly (N-Iso-Propylacrylamide-co-Lucifer Yellow) particles for drug delivery applications. OMICS International. In: , , , . OMICS International, Journal of Nanomedicine and Nanotechnology, 7: 1000363 (2) . pp. 363-372 ISSN: 2157-7439 (Print), (doi: http://dx.doi.org/10.4172/2157-7439.1000363).

Bhomia, Ruchir , Trivedi, Vivek, Coleman, Nichola J., Mitchell, John C. (2016), The thermal and storage stability of bovine haemoglobin by ultra violet–visible and circular dichroism spectroscopies. Elsevier. In: , , , . Elsevier, Journal of Pharmaceutical Analysis, 6 (4) . pp. 242-248 ISSN: 2095-1779 (Print), 2214-0883 (Online) (doi: https://doi.org/10.1016/j.jpha.2016.02.004).

Ehiwe, Tracy O. , Alexander, Bruce D, Mitchell, John C., Snowden, Martin J. , Waters, Laura J. (2016), Monitoring real time polymorphic transformation of sulfanilamide by diffuse reflectance visible spectroscopy. Elsevier. In: , , , . Elsevier, Journal of Pharmaceutical Analysis, 6 (3) ISSN: 2095-1779 (Print), 2214-0883 (Online) (doi: http://dx.doi.org/10.1016/j.jpha.2015.12.002).

Mitchell, John , Wicks, Stephen, Trivedi, Vivek, Waters, Laura , Ehiwe, Tammy (2015), Continuous tank reactor synthesis of highly substituted sulphobutylether β-cyclodextrins. Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics, 495 (2) . pp. 862-868 ISSN: 0378-5173 (Print), 1873-3476 (Online) (doi: https://doi.org/10.1016/j.ijpharm.2015.09.039).

Rudrangi, Shashi Ravi Suman , Trivedi, Vivek, Mitchell, John C., Wicks, Stephen Richard , Alexander, Bruce David (2015), Preparation of olanzapine and methyl-β-cyclodextrin complexes using a single-step, organic solvent-free supercritical fluid process: An approach to enhance the solubility and dissolution properties. Elsevier. In: , , , . Elsevier, International Journal of Pharmaceutics, 494 (1) . pp. 408-416 ISSN: 0378-5173 (Print), 1873-3476 (Online) (doi: https://doi.org/10.1016/j.ijpharm.2015.08.062) NB Item availability restricted.

Boateng, Joshua , Momoh, Frederick, Richardson, Simon, Chowdhry, Babur , Mitchell, John (2015), Development functional characterization of alginate dressing as potential protein delivery system for wound healing. Elsevier. In: , , , . Elsevier, International Journal of Biological Macromolecules, 81 . pp. 137-150 ISSN: 0141-8130 (Print), 1879-0003 (Online) (doi: http://dx.doi.org/10.1016/j.ijbiomac.2015.07.037).

Rudrangi, Shashi Ravi Suman , Bhomia, Ruchir, Trivedi, Vivek, Vine, George J. , Mitchell, John C. , Alexander, Bruce David , Wicks, Stephen Richard (2015), Influence of the preparation method on the physicochemical properties of indomethacin and methyl-β-cyclodextrin complexes. Elsevier B.V.. In: , , , . Elsevier B.V., International Journal of Pharmaceutics, 479 (2) . pp. 381-390 ISSN: 0378-5173 (Print), 1873-3476 (Online) (doi: https://doi.org/10.1016/j.ijpharm.2015.01.010) NB Item availability restricted.

Khan, Sajjad , Boateng, Joshua S., Mitchell, John, Trivedi, Vivek (2015), Formulation, characterisation and stabilisation of buccal films for paediatric drug delivery of omeprazole. Springer US. In: , , , . Springer US, AAPS PharmSciTech: An Official Journal of the American Association of Pharmaceutical Scientists, 16 (4) . pp. 800-810 1530-9932 (Online) (doi: https://doi.org/10.1208/s12249-014-0268-7) NB Item availability restricted.

Boateng, Joshua S. , Mitchell, John C., Pawar, Harshavardhan, Ayensu, Isaac (2014), Functional characterisation and permeation studies of lyophilised thiolated chitosan xerogels for buccal delivery of insulin. Bentham Science Publishers. In: , , , . Bentham Science Publishers, Protein & Peptide Letters, 21 (11) . pp. 1163-1175 ISSN: 0929-8665 (Print), 1875-5305 (Online) (doi: http://dx.doi.org/10.2174/0929866521666140805124403) NB Item availability restricted.

Bhomia, Ruchir , Trivedi, Vivek, Mitchell, John, Coleman, Nichola , Snowden, Martin (2014), Effect of pressure on the melting point of pluronics in pressurized carbon dioxide. American Chemical Society. In: , , , . American Chemical Society, Industrial & Engineering Chemistry Research, 53 (26) . pp. 10820-10825 ISSN: 0888-5885 (Print), (doi: http://dx.doi.org/10.1021/ie501344m).

Pettit, Marie , Dyer, Paul D.R., Mitchell, John C., Griffiths, Peter C. , Alexander, Bruce , Cattoz, Beatrice , Heenan, Richard K. , King, Stephen M. , Schweins, Ralf , Pullen, Frank (2014), Construction and physiochemical characterisation of a multi-composite, potential oral vaccine delivery system (VDS). Elsevier B.V.. In: , , , . Elsevier B.V., International Journal of Pharmaceutics, 468 (1-2) . pp. 264-271 ISSN: 0378-5173 (Print), (doi: http://dx.doi.org/10.1016/j.ijpharm.2014.03.046) NB Item availability restricted.

Conference item

Khan, S. , Boateng, J.S., Okeke, O., Trivedi, V. , Mitchell, J.C. (2014), Physico-chemical characterization of oral thin film for paediatric buccal drug delivery. Academy of Pharmaceutical Sciences. In: APS PharmSci 2014, 8-10 Sep 2014, University of Hertfordshire, Hatfield, UK , UKPHARMSCI Conference. Academy of Pharmaceutical Sciences, (doi: https://www.ukpharmsci.org/2014ResourcePack/Default.asp) NB Item availability restricted.

Trivedi, Vivek , Bhomia, Ruchir, Mitchell, John (2014), The preparation of solid core drug delivery systems (SCDDS) for the biomolecular delivery. In: 14th European Meeting on Supercritical Fluids (EMSF), 18-21 May 2014, Marseille, France , . , (doi: ).

Bhomia, Ruchir , Trivedi, Vivek, Mitchell, John (2014), A study on melting point depression of fatty acids and Pluronics® in liquid or supercritical carbon dioxide. In: 14th European Meeting on Supercritical Fluids (EMSF) 2014, 18-21 May 2014, Marseille, France , . , (doi: ).

Conference proceedings

Boateng, Joshua , Mitchell, John, Trivedi, Vivek, Khan, Sajjad (2014), Formulation and characterisation of oral thin films for buccal mucosa drug delivery for paediatric patients. Athens Institute for Education and Research. In: Annual International Conference on Pharmaceutical Sciences, 5-8 May 2014, Athens, Greece In: Gregory T. Papanikos (ed.), Pharmaceutical Sciences Abstracts: Annual International Conference on Pharmaceutical Sciences. 5-8 May 2014, Athens, Greece. Athens Institute for Education and Research, Athens, Greece . pp. 30-31 . ISBN: 9786185065355 (doi: http://www.atiner.gr/abstracts/2014ABST-PHA.pdf) NB Item availability restricted.

Patent

Savage, Tammy , Wicks, Stephen, Mitchell, John (2019), Cyclodextrin. US Patent App. 10/239,961. In: , , , . US Patent App. 10/239,961, (doi: https://patents.google.com/patent/US10239961B2/en).

Mitchell, John , Wicks, Stephen, Savage, Tammy (2016), US20160024229A1 Cyclodextrin. In: , , , . , (doi: http://google.com/patents/US20160024229?cl=en) NB Item availability restricted.

Mitchell, John and , Wicks, Stephen (2015), WO2015008066A1: Cyclodextrin US 20150025023 A1. In: , , , . , (doi: http://www.google.com/patents/US20150025023).

Richardson, Simon , Dyer, Paul D.R., Mitchell, John (2014), WO 2014203008 A1 Antisense oligonucleotide compositions. In: , , , . , (doi: https://www.google.co.in/patents/WO2014203008A1?cl=en) NB Item availability restricted.