Preformulation, Reformulation and Co-formulation

Faculty

Preformulation Studies provide the foundational understanding of API–excipient compatibility, stability, solubility, and physicochemical behaviour. These include:

  • Salt, hydrate and polymorph screening
  • Solubility/permeability studies (BCS guidance)
  • Bulk powder characterisation: particle size, hygroscopicity, true density, flow
  • pH and buffer tolerance studies
  • Excipient compatibility and thermal stability

Reformulation Services are available for:

  • Enhancing product shelf life, palatability, and bioavailability.
  • Modifying release profiles (immediate, delayed, or extended)
  • Reformulating liquids into solid forms, or vice versa.
  • Transitioning conventional formulations to modern excipients or delivery technologies

Co-formulation Projects support dual APIs or fixed-dose combinations with attention to:

  • Compatibility and stability of actives within a single matrix
  • Release synchronisation or segregation
  • Taste masking and targeted delivery
  • Regulatory guidance for complex multi-component dosage forms